IndraLab

"Our study explores the function and mechanism of the CALR-TLR4 complex in DC migration and maturation and investigates the inhibitory effect of the CALR-TLR4 complex on lung cancer progression, providing a theoretical basis and ideas for immunotherapy of NSCLC."

"Our study explores the function and mechanism of the CALR-TLR4 complex in DC migration and maturation and investigates the inhibitory effect of the CALR-TLR4 complex on lung cancer progression, providing a theoretical basis and ideas for immunotherapy of NSCLC."

"CRT, ATP and HMGB1 bind to CD91, P2RX7 and TLR4, respectively, and promote the recruitment of DCs into the tumor bed, the engulfment of tumor antigens, and optimal antigen presentation to T cells [79][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Our study demonstrates the inhibitory effect of the CALR-TLR4 complex on NSCLC progression and provides a theoretical basis for NSCLC immunotherapy."

"A recent study showed that the CALR-TLR4 complex inhibits NSCLC progression by regulating the migration and maturation of DCs, providing a theoretical basis and ideas for immunotherapy of NSCLC [ xref ]."

"A recent study showed that the CALR-TLR4 complex inhibits NSCLC progression by regulating the migration and maturation of DCs, providing a theoretical basis and ideas for immunotherapy of NSCLC [109]."

"Our study demonstrates the inhibitory effect of the CALR-TLR4 complex on NSCLC progression and provides a theoretical basis for NSCLC immunotherapy."

"Our study demonstrates the inhibitory effect of the CALR-TLR4 complex on NSCLC progression and provides a theoretical basis for NSCLC immunotherapy ( Figure 7 )."

"Our study demonstrates the inhibitory effect of the CALR-TLR4 complex on NSCLC progression and provides a theoretical basis for NSCLC immunotherapy ( xref )."

"Alternatively, as a proteolytic fragment of calreticulin has previously been shown to activate myeloid cells via TLR4/CD14 (50), it is possible that full-length calreticulin binds to TLR4 or CD14 to activate microglia.We found that calreticulin affected Aβ aggregation."

"Moreover, the interaction between calreticulin and toll-like receptor 4 (TLR4) expressed on tumor cell surface promotes the secretion of TNFα and CCL19, which facilitates the migration and maturation of DCs, to limit the tumor progression in vivo (49)."

"Studies have showed that after anthracyclines treatment of NSCLC tumor cells, calreticulin (CALR) on the cell membrane interacts with its own receptor TLR4 to activate the CALR-TLR4-MyD88 signaling pathway, phosphorylating NF-κB, JNK, ERK, p38 MAPK and other signaling pathways. xref , xref Subsequently secreted C-C motif chemokine ligand 19 (CCL19) and TNF-α promote the migration and maturation of imDCs, ultimately inhibiting NSCLC progression. xref In mouse lung cancer models, S. Hillinger et al identified CCL19 as a potential immune stimulator that significantly increases DCs in the lung. xref In addition, TNF-α exhibits strong inflammatory and tumor-promoting properties and can influence tumor progression through complex signal transduction phenomena, including NF-κB, MAPK, AKT, etc. xref A study revealed that CD34 + /CD86 +  cells, common precursors for macrophages and DCs, differentiate into macrophages when cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF)."

"Calreticulin, ATP, and HMGB1 bind to CD91, P2RX7, and TLR4, respectively, facilitating dendritic cell (DC) recruitment into the tumor bed (by ATP), the phagocytosis of tumor antigens by DCs (enhanced by CRT), and an optimal antigen presentation to T cells (stimulated by calreticulin and HMGB1)."

"CRT, ATP and HMGB1 bind to the low density lipoprotein-related protein (CD91), 7 purinergic receptor P2X (P2RX7, an important member of the purinergic receptor P2X family, distributed in various tissu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Calreticulin, HMGB1 and HSPs, and ATP then interact with the receptors CD91, Toll like receptor 4 (TLR4), and purinergic P2X7 receptors, respectively, which are present on the surface of DCs."