IndraLab

Statements

UCHL1-I93M inhibits hydrolase. 3 / 3
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"Notably, the I93M UCHL1 mutant has markedly reduced ubiquitin hydrolase activity in vitro [XREF_BIBR], suggesting that impaired polyubiquitin hydrolysis could also contribute to dopaminergic neuronal death."
18047737
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"The UCH-L1 I93M mutant displays significant decreased hydrolase activity in vitro, implying that loss of UCH-L1 function may contribute to a decrease in the availability of free ubiquitin, and an impaired clearance of proteins by the Ubiquitin Proteasome System (UPS)."
22514658
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"Notably, the I93M UCHL1 mutant display markedly reduced ubiquitin hydrolase activity in vitro; suggesting that impaired polyubiquitin hydrolysis leading to a shortage of free ubiquitin might also promote the accumulation of toxic proteins and contribute to neuronal death."
24532982