IndraLab

Statements

HCN1 activates ketamine. 8 / 8
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"We suggest that ketamine inhibition of HCN1 shifts cortical neuron electroresponsive properties to contribute to ketamine induced hypnosis."
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"This new result suggests that forebrain HCN1 channels contribute to ketamine induced hypnosis, but does not rule out significant contributions by hindbrain HCN1 channels or by other channels affected by ketamine."
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"Therefore, the extant data support the hypothesis that NMDAR antagonism mediates the antidepressant effects of esketamine.Nevertheless, a recent preclinical study hypothesized that the hyperpolarization-activated cyclic-nucleotide-gated potassium channel 1 (HCN1) mediates the dissociative effects of ketamine (Vesuna et al., 2020)."
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"To localize the brain region responsible for HCN1 mediated hypnotic actions of ketamine, we employed a conditional knockout strategy to delete HCN1 channels selectively in excitatory cells of the mouse forebrain."
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"To localize the brain region responsible for HCN1 mediated hypnotic actions of ketamine, the authors used a conditional knockout strategy to delete HCN1 channels selectively in excitatory cells of the mouse forebrain."
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"Thus, the accumulated evidence available to this point is consistent with the idea that forebrain HCN1 channels indeed contribute to ketamine induced hypnosis."
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"The authors suggest that ketamine inhibition of HCN1 shifts cortical neuron electroresponsive properties to contribute to ketamine induced hypnosis."
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"HCN1 mediated interactions of ketamine and propofol in a mean field model of the EEG."
| PMC