IndraLab

Statements

NOS1 binds SCN5A and SNTA1. 3 / 3
| 3
sparser
"We also performed immunoprecipitation with FLAG antibody using a FLAG-tagged SCN5A co-expressed with nNOS, SNTA1, and Cav3 (WT, F97C, or vector) in HEK cells and found that the complex remained intact with the mutant Cav3 ( xref ) Taken together, these results demonstrate that nNOS, SCN5A and SNTA1 form a complex with Cav3 in the heart."
23541953
sparser
"Based on the associations of nNOS, SNTA1, PMCA4b [ xref ] and SNTA1 with SCN5A [ xref ], the full complex ( xref ) was demonstrated in mouse heart by co-IP [ xref ]."
23557754
sparser
"These three proteins Snta1, nNOS, and Pcma4b associate with the c-terminus of NaV1.5, and the mutation A390V in Snta1, discovered in a patient with long-QT syndrome, specifically disrupts binding of PCMA4b from the complex [ xref ]."
26092781