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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

SCN5A binds SNTA1 and NOS1. 2 / 2

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"Based on the associations of nNOS, SNTA1, PMCA4b [ xref ] and SNTA1 with SCN5A [ xref ], the full complex ( xref ) was demonstrated in mouse heart by co-IP [ xref ]."

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"We also performed immunoprecipitation with FLAG antibody using a FLAG-tagged SCN5A co-expressed with nNOS, SNTA1, and Cav3 (WT, F97C, or vector) in HEK cells and found that the complex remained intact with the mutant Cav3 ( xref ) Taken together, these results demonstrate that nNOS, SCN5A and SNTA1 form a complex with Cav3 in the heart."

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