IndraLab

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Modified USP15 inhibits SMURF2. 1 / 1
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reach
"Importantly, when we analyzed the ubiquitination pattern of these SMURF2 mutants in lysates of transfected HEK293T cells in the presence of USP15 knockdown vectors, we found that, in addition to wild type SMURF2, loss of USP15 only enhanced SMURF2 ubiquitination in the SMURF2 (K0-734) variant, but not in SMURF2 (K0) " lysine less " mutant (XREF_FIG)."