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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Modified USP15 inhibits SMURF2. 1 / 1

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"Importantly, when we analyzed the ubiquitination pattern of these SMURF2 mutants in lysates of transfected HEK293T cells in the presence of USP15 knockdown vectors, we found that, in addition to wild type SMURF2, loss of USP15 only enhanced SMURF2 ubiquitination in the SMURF2 (K0-734) variant, but not in SMURF2 (K0) " lysine less " mutant (XREF_FIG)."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...