IndraLab

Statements

ZUP1 inhibits NFkappaB. 3 / 3
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"A20 is an OTU domain DUB that inhibits NF-kB upstream by removing ubiquitin from TRAF6 and RIP1, two signaling molecules of the NF-kB pathway."
19527883
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"The YopJ DUB inhibits NF-kB and mitogen-activated protein kinase (MAPK) pathways, a function ascribed previously to its somewhat promiscuous deubiquitination of critical cellular proteins, such as TRAF2, TRAF6, and IkB."
17145306
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"Conversely, CYLD, a human DUB that negatively regulates the NF-kB pathway, is specific for K63-based Ub chains."
24854014