IndraLab

Statements

AKT phosphorylates MAP3K5 on T838. 4 / 4
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rlimsp
"Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase, which has been reported to be phosphorylated by Akt at serine 83 (Ser83) or threonine 838 (Thr838), resulting in the reduced or increased activity respectively."
28335665
sparser
"Moreover, it has been reported that ASK1 can be phosphorylated at Thr838 directly by Akt kinases to prompt cell apoptosis. xref By Western blot, we observed a pronounced activation of Akt in MDCK cells exposed to COM crystals ( xref )."
28335665
reach
"Moreover, it has been reported that ASK1 can be phosphorylated at Thr838 directly by Akt kinases to prompt cell apoptosis."
28335665
rlimsp
"Given the results that we obtained in siRNA ASK1 (Figure 3C) that p38 phosphorylation was almost completely inhibited by siRNA ASK1, we propose that Akt may phosphorylate ASK1 at Thr838 first, followed by p38 phosphorylation."
20112989