IndraLab

Statements

PTEN inhibits AKT1. 40 / 91
2 | 2 36
reach
"By opposing PI3K signaling, PTEN inhibits the activation of the critical PI3K effector proteins Akt1-3 (also known as protein kinase B or PKB)."
17786934
signor
"Exposure of eol-1r cells to imatinib failed to dephosphorylate akt, erk and stat5, although pdgfralpha was effectively inactivated. The forced expression of pten negatively regulated these signal pathways and sensitized eol-1r cells to imatinib."
20596030
eidos
"Specifically , PTEN dephosphorylates PIP3 , preventing Akt1 activation , thereby directly antagonizing the PI3K function and blocking , therefore the activation of downstream signaling events , including PDK1 , ( Akt ) and Akt / mammalian target of rapamycin ( mTOR ) ( Gingras et al ., 2001 ) ."
30255690
reach
"On the other hand, AKT1 is negatively regulated by PTEN, a p53 response gene that is inactivated in a variety of cancers XREF_BIBR."
24632578
reach
"Interestingly and as expected, overexpression of PTEN, the negative regulator of the PI3K signaling that is inhibited by PPARbeta, did not affect the upregulation of PDK1 and ILK by LD but abrogated t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12419217
reach
"PTEN is a natural inhibitor of AKT1, an oncogenic kinase that acts downstream of PI3K to control proliferation and survival."
24764758
reach
"Akt1/2 deletion results in inhibited proliferation of HSCs and impaired long-term function (Juntilla et al., 2010), while aberrant activation of Akt-mTOR signaling by PTEN deletion or overexpression of Akt1 leads to quiescence exit and eventual exhaustion of HSCs (Yilmaz et al., 2006; Kharas et al., 2010)."
33755722
reach
"We speculate that AKT1 activation was negatively regulated by PTEN and that PTEN/PI3K/AKT signaling was not the only influence on the growth of KS."
30170375
reach
"Expression of PTEN in the MDAMB-231BR subline reduced the activity of Akt1 to the level observed in the less aggressive MDA-MB-231 WT cells."
28008153
reach
"DAF-18 PTEN may normally limit AKT-1 and AKT-2 activation by decreasing PIP3 levels."
9885576
reach
"Here, the Notch signal was not activated, while the tensin homologue deleted on human chromosome 10 (PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B (Akt)."
30455992
reach
"The pathway analysis using the Reactome database showed stabilization of PTEN, which down-regulates PI3K/AKT1, which in turn down-regulates Nrf2, as shown by ELISA, thus disabling antioxidant production, resulting in high oxidative stress levels."
34536049
reach
"It must be noted that PTEN, one of the genes mutated in familial breast cancer, is an antagonist of AKT1."
24966870
reach
"Phosphatase and tensin homolog (PTEN) negatively regulates downstream protein kinase B signaling, resulting in decreased cellular growth and proliferation."
29373119
reach
"Recent studies have shown that a loss of PTEN causes continuous activation of protein kinase B (Akt), which is critical in the phosphoinositide 3-kinase (PI3K)-Akt pathway that leads to cell proliferation.9, 10, 11 When NSCLC with low PTEN expression is treated with TKIs, resistance will occur.12 Therefore, TKI resistance could be reversed by upregulating PTEN expression levels."
27385992
reach
"Result also showed that CTN could increase expression levels of PTEN, and reduce the phosphorylated levels of Akt (protein kinase B) on Thr 308 and Ser 473 domain."
28088493
reach
"In addition, a different study demonstrated that loss of PTEN promoted melanoma cell metastasis via activating Akt2 but not Akt1 or Akt3 [XREF_BIBR]."
21461351
reach
"Overexpression of Akt-1 enhances FAS gene expression, while PTEN inhibits Akt-1 activation and thus negatively regulates the expression of FAS [XREF_BIBR, XREF_BIBR]."
22949843
reach
"Signaling through S1PR4 in myoblasts involved activation of ROCK2, leading to phosphatase and tensin homolog (PTEN) phosphorylation and subsequent inhibition of protein kinase B (PKB and AKT) signaling."
28848247
reach
"Loss of PTEN leads to the constitutive activation of AKT1, which stimulates glucose uptake by enhancing GLUT4 expression and activating HK2."
30895167
reach
"The restoration of PTEN expression may block angiogenesis in GC by inactivating the PI3K and protein kinase B (AKT) pathway [XREF_BIBR]."
| PMC
reach
"Constitutive activation of Akt1 kinase occurs in human cancer through deletion and mutation of the tumor suppressor gene PTEN, the phosphatase that negatively regulates Akt1, through amplification of the Akt1 genes, or through amplification of the catalytic subunit of PI3 kinase."
24658544
reach
"By removing the D3 phosphate from D3 phosphorylated phosphoinositides, PTEN inhibits the activation of not only Akt2, but also Akt1 and Akt3."
21555366
reach
"Similarly, overexpression of PTEN inactivates Akt1 [36] and causes a decrease in cell size [38-40]."
12928036
signor
"PTEN-mediated suppression of the PI3K/AKT pathway is well established, accumulating evidence suggests that nuclear PTEN also plays a critical role in tumor suppression"
19903340
reach
"PTEN overexpression in 3T3-L1 adipocytes inhibited serine threonine kinase protein kinase B (Akt) activation and glucose uptake."
28413472
reach
"PTEN, in turn, reduces the phosporylation of Akt1, also observed in our experiments."
19050264
reach
"AKT1 is mutated and AKT2 is amplified in about 40% AKT1 is inhibited by tumor suppressors including phosphatase and tensin homolog (PTEN) and inositol polyphosphate 4-phosphatase type 2 INPP4B [8, 9]."
34727985
reach
"AKT1 is positively regulated by PAR1, TIS21 and caveolin-1 [XREF_BIBR] and negatively regulated by PIPP, miR409-3p [XREF_BIBR], PTEN, SHIP, PHLPP, and PP2A."
33291460
reach
"Whereas PTEN and Delta85 both inhibited activation of AKT and protein kinase B, only Deltap85 inhibited c-Jun NH2-terminal kinase (JNK) activity."
12714585
reach
"Furthermore, overexpression of miR-494-3p inhibited PTEN expression and consequently activated the downstream phosphoinositide3-kinase and protein kinaseB (PI3K and AKT) signialing pathway."
30431102
reach
"In recent studies, there has been consensus that a high percentage of PTEN loss and presence of p-Akt1 in TNBC indicates poor disease-free survival [XREF_BIBR]."
25389442
eidos
"HOXA5 is controlled by DNA methylation [ 48 ] , and has been shown to up-regulate the tumor suppressor p53 and AKT1 by down-regulation of PTEN [ 49 ] ."
30442871
reach
"The PTEN tumor suppressor gene is frequently inactivated in human prostate cancers, particularly in more advanced cancers, suggesting that the AKT and protein kinase B (PKB) kinase, which is negatively regulated by PTEN, may be involved in human prostate cancer progression."
10827191
reach
"A previous study demonstrated that increased PTEN may decrease spermatogenesis, fertility, and sperm maturation, and fertilization in the Akt1-/- and Akt2-/- male mice XREF_BIBR."
26865000
reach
"Daf-18 mutation did not enhance gonad disruption of akt-1 (ok525) one day adult animals (XREF_FIG, XREF_TABLE), suggesting that active PI3K is not sufficient for DAF-16 to degenerate the basement membrane."
22916022
reach
"PTEN antagonizes the AKT1 and PI3K signaling pathway and has roles in cell cycle, migration, cell polarity, and apoptosis."
23246288
reach
"Decreased AKT1 signaling mediated by increased PTEN downregulates both TGFB and canonical WNT signals, suggesting that this pathway may synergize in the observed increase in G0 and delayed time to first division."
26527384
reach
"Thus, haplodeficiency of Pten was sufficient to reverse the type 2 diabetes phenotype of Akt1 +/- Akt2 -/- mice to a pre-diabetic, insulin resistant state, similar to that observed in Akt2 -/- mice [XREF_BIBR]."
20947368
reach
"AKT1 can be suppressed by phosphatase and tensin homolog deleted on chromosome 10 (PTEN) to result in the inhibition of phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway in GC [XREF_BIBR]."
33336058