IndraLab

Statements

SCN10A binds cre. 52 / 52
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"Cold allodynia but not mechanical allodynia induced by pT-ION or by virus-mediated overexpression of Cx36 in the trigeminal ganglion was reversed by the GluK2 antagonist NS102, and knocking down Cx36 expression in Nav1.8-expressing nociceptors by injecting virus into the orofacial skin area of Nav1.8-Cre mice attenuated cold allodynia but not mechanical allodynia."
33067780
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"Characterization of Nav1.8-cre;tdTomato mice showed robust corneal afferent neuronal labeling, including the subbasal nerve plexus and intraepithelial nerve terminals."
33057056
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"By contrast, the dsDNA analogue poly(dA:dT) resulted in antinociception in wild-type and RIG-I −/− mice, but these effects were abolished in Ifnar1 fl/fl ;Nav1.8-cre, STING gt/gt and Cgas −/− mice, and each of which also exhibited baseline mechanical hypersensitivity ( xref )."
33442058
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"Dta +/+ mice to generate Nav1.8-cre +/− ; Dta mice and control littermates (Nav1.8-cre −/− ; Dta)."
29505031
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"CNO treatment of Nav1.8-Cre(+/-) mice did not cause p-CREB up-regulation in DRG."
33711031
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"However, the large reduction in tearing quantified in the Nav1.8-cre;tdTomato mice after single LGE in both female and male mice is consistent with our previous study using this model xref ."
33057056
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"Nav1.8-cre +/− mice were bred with diphtheria toxin A (DTA) reporter mice to generate animals deficient in Nav1.8-lineage neurons (Nav1.8-Cre +/− ; Dta) 21 ."
29505031
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"After LGE, Nav1.8-cre;ArchT/eGFP mice demonstrated a preference for the ArchT activating light paired chamber."
34787642
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"Another study has shown that Nav1.8-Cre; Dta mice still possess CGRP+ neurons expressing TRPV1 (ref."
29505031
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"Nav1.8-Cre is expressed in numerous functional classes of afferents, including C-LTMRs ( xref )."
31324538
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"Nav1.8-cre +/− mice were bred with B6."
29505031
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"We found a similar increase in γδ T cells in Nav1.8-Cre +/− ; Dta mice compared with control littermates ( xref ). γδ T cells reside within epithelial layers of the lungs, skin, and gut, where they act as first responders to infection xref ."
29505031
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"By lineage tracing, Nav1.8-Cre targeted peripheral sensory neurons, a subpopulation of postganglionic sympathetics, and several regions of the brain."
36586433
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"Nav1.8-cre mice21 were originally from J. Wood (University College London)."
29505031
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"Although it is possible that Cre expression in dorsal root ganglia in the Nav1.8-Cre mice may not be restricted to nociceptors and may also affect low threshold mechanoreceptor sensory neurons ( xref ), it remains unclear whether deletion of DORs solely on nociceptors is responsible for the enhancement of mechanical pain."
32623788
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"Corneal axons were visualized using Nav1.8-Cre;tdTomato reporter mice."
35240196
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"To examine corneal innervation, the Nav1.8-cre;tdTomato reporter mouse line was utilized, since the voltage-gated sodium channel Nav1.8 is preferentially expressed in C-fibers, including > 90% of IB4-binding neurons (nonpeptidergic C-fibers) and CGRP-positive neurons (peptidergic C-fibers) xref ."
33057056
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"The dsRNA analogue Poly(I:C) led to antinociception with similar kinetics in wild-type, STING gt/gt and Cgas −/− mice, but these effects were abolished in Ifnar1 fl/fl ;Nav1.8-cre ( Ifnar1 -cKO) and RIG-I −/− mice ( xref )."
33442058
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"Innervation of the cornea was visualized in whole-mounted corneas using a tdTomato fluorescent reporter expressed with the Nav1.8-Cre promoter."
35240196
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"Nav1.8-cre ; Dta mice, in which an overlapping though distinct nociceptor subset is targeted, showed a milder protective phenotype."
29505031
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"However, the same loss of Npy2r expression and impairment of pinprick-evoked responses were found in Nfia F/F ;Nav1.8-Cre mice (Fig.  xref A–D), in which the Cre recombinase is confined to DRG neurons, not in spinal neurons [ xref , xref ]."
32221845
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"As most corneal axons were labeled with tdTomato, subsequent studies quantified innervation density using the Nav1.8-Cre;tdTomato reporter, conducting an overlayed Sholl analysis on the max projection z-stack images."
35240196
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"We found a similar increase in γδ T cells in Nav1.8-Cre +/− ; Dta mice compared with control littermates (Supplementary Fig. 24 ). γδ T cells reside within epithelial layers of the lungs, skin, and gut, where they act as first responders to infection 27 ."
29505031
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"To mirror this in mice, we bred Nav1.8-Cre with TSC2 fl/fl animals to conditionally delete TSC2 in Nav1.8-expressing neurons."
36586433
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"Furthermore, mouse models more specific to sensory nerves can be used for comparison, such as Nav1.8‐Cre mice."
33112056
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"Another study has shown that Nav1.8-Cre ; Dta mice still possess CGRP + neurons expressing TRPV1 (ref. xref )."
29505031
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"An alternative germline model of sensory nerve Y2R knockdown was generated using Nav1.8-Cre mice crossed with the Y2R-flox strain (Nav1.8-Y2R-KD)."
| PMC
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"Similarly, when a large portion of nociceptive neurons were depleted using Nav1.8-Cre lineage ablation in mice, monocyte recruitment and lymphadenopathy increased in a Staphylococcus aureus subcutaneous infection model; CGRP also decreased TNFα production from macrophages ( xref ) [ xref ]."
31213389
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"In Nav1.8-Cre +/− ; Dta mice, compared with control littermates, we also observed significantly greater bacterial dissemination to the blood, which was accompanied by greater spleen size (Supplementary Fig. 13 )."
29505031
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"Nav1.8-cre +/− mice were bred with diphtheria toxin A (DTA) reporter mice to generate animals deficient in Nav1.8-lineage neurons ( Nav1.8-Cre +/− ; Dta ) xref ."
29505031
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"As previously described, the ZBTB20 gene is deleted specifically in nociceptors at E14 using Nav1.8-Cre, but deletion of this gene does not affect the formation, survival or diversification of nociceptors ( xref )."
33748159
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"In Nav1.8-Cre +/− ; Dta mice, compared with control littermates, we also observed significantly greater bacterial dissemination to the blood, which was accompanied by greater spleen size ( xref )."
29505031
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"The corneal afferent nerves and trigeminal ganglion cell bodies showed a robust eGFP signal in Nav1.8-cre;ArchT/eGFP mice."
34787642
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"Mice heterozygously expressing Cre recombinase under the control of the Na V 1.8 promoter ( SNS-Cre ; xref ) were crossed with homozygous mice carrying the Nedd4-2 floxed allele (Nedd4L fl/fl ; xref )."
35131865
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"To explore the role of Nav1.8+ sensory nerves within the tumour microenvironment, we have induced targeted diphtheria toxin‐based cell ablation. xref We crossed Nav1.8‐Cre mice with inducible diphtheria toxin A (iDTA) transgenic mice to specifically deplete all sensory neurons. xref Nav1.8‐Cre/iDTA mice were previously shown to be devoid of all Nav1.8‐expressing nociceptors, xref and have no response to mechanical stimuli, noxious heat or capsaicin. xref Genetic depletion of sensory nerves was confirmed by immunohistochemistry to Nav1.8 in the dorsal root ganglions of these animals (Figure xref C,D)."
32691511
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"The proton pump archaerhodopsin-3/eGFP (ArchT/eGFP) was conditionally expressed in corneal afferents using Nav1.8-cre mice."
34787642
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"After MRSA infection, we observed a trend toward higher survival (P = 0.09) and lower bacterial burden (P = 0.07) in Nav1.8-Cre +/− ; Dta mice than in control littermates (Supplementary Fig. 8) ."
29505031
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"Using Nav1.8-cre;tdTomato mice, corneal innervation was investigated and analyzed using Sholl and pixel analysis."
33057056
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"Robust labeling of the subbasal nerve plexus and intraepithelial terminals were observed in the corneas of Nav1.8-cre;tdTomato mice (Fig.  xref A)."
33057056
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"To study cell-specific pathways, we generated mice expressing an HA-tagged ribosomal protein (RPL22-HA) in the sensory neurons (RiboTag+/+:Nav1.8Cre+/–; RiboTag-Nav) by crossing RiboTag mice with hemizygous Nav1.8-Cre mice (RiboTag mice procedure; xref )."
30304667
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"We have crossed Nav1.8‐Cre mice with a mouse line conditionally expressing TdTomato. xref In Nav1.8‐Cre/TdTomato mice, upon removal of loxP‐stop‐loxP cassette by Cre recombination, TdTomato is expressed only in Nav1.8‐sensory neurons."
32691511
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"Nav1.8-cre;ArchT/eGFP mice with sham surgery and LGE wild-type control mice did not develop preference."
34787642
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"The use of the Nav1.8-Cre;tdTomato reporter appeared to label the vast majority of corneal afferents, with the likely exception of autonomic neurons and up to 80% of cool sensing neurons that do not express Nav1.8, indicating that use of this mouse could be a valuable tool in longitudinal studies to track corneal sensory innervation ( xref ; xref )."
35240196
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"Next, we used Nav1.8-Cre; Rosa26 LSL-DTR mice to ablate Nav1.8 + neurons by expressing human diphtheria toxin (DTX) receptor (DTR) in these neurons."
31324538
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"Conditional deletion of Dicer in the dorsal root ganglion by using Nav1.8-Cre mice leads to the attenuation of nociception-related gene expression and the reduction of inflammatory pain while maintaining intact acute nociception [ xref ]."
30627562
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"Using Nav1.8-Cre;tdTomato mice to examine corneal innervation, we observed an almost complete loss of axon terminals through superficial layers of the corneal epithelium to the subbasal nerve plexus at 7-days following LGE in both male and female mice."
35240196
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"To determine novel bacterial mechanisms which may modulate pain-related signaling, we mined our mouse transcriptional dataset of FACS-sorted DRG neuron populations xref and found that Antxr2 was enriched by 5-fold in Na v 1.8 lineage ( Nav1.8-cre Rosa26-Tdtomato +) neurons compared to Parvalbumin lineage ( Pvalb-cre Rosa26-Tdtomato +) proprioceptive neurons ( xref )."
34931070
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"After MRSA infection, we observed a trend toward higher survival ( P = 0.09) and lower bacterial burden ( P = 0.07) in Nav1.8-Cre +/− ; Dta mice than in control littermates ( xref )."
29505031
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"Viewed with TEM, the ultrastructure of pathological Nav1.8 Cre/+ ;ROSA26 lacZ /+afferents ( xref ) was similar to those of theKcna6 lacZ/lacZ mice ( xref ), while normal morphology of primary afferent terminals was observed in Nav1.8-Cre negative littermate controls ( xref ) and in Kcna6 -/- knock-out mice not expressing lacZ ( xref )."
34544832
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"Nav1.8-Cre; tdTomato labeling of corneal innervation was validated using PGP9.5 as a pan-neuronal marker in a naïve Nav1.8-Cre; tdTomato animal."
35240196
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"A previous study, also using Nav1.8-Cre;tdTomato mice, found no difference in innervation density at 14-days after excision of only the extraorbital lacrimal gland ( xref ), indicating that the severity of dry eye likely contributed to the amount of denervation observed in the present study."
35240196
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"To study leptin resistance in the peripheral nervous system, we have previously reported the mice (Nav1.8-Cre X LepR fl/fl , VAN LepRΔ ) with deletion of leptin receptor in sensory neurons, primarily vagal afferent neurons (VAN) [ xref ]."
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