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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMD14 inhibits proteolysis. 2 / 2

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"Rpn11-inhibited proteasomes can therefore move this substrate far enough into the 20S core for proteolysis near fluorescein, before translocation stalls on the K2-attached ubiquitin chain ."

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"POH1 knockdown could dramatically inhibit GFPu protein degradation in HEK-293 cells and induce ubiquitinated protein accumulation in HepG2 cancer cells, and this disassembly of 26S proteasome could mostly blocked the effects of CuPT on protein degradation and ubiquitinated protein accumulation, indicating that CuPT mediated proteasome malfunction did rely on the existence of intact 26S proteasome."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...