IndraLab

Statements

UCHL5 ubiquitinates PGK1. 3 / 3
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"Silencing of ADRM1 or UCH37 also suppressed the downregulation of pro-SFTPB-induced upregulation of PGK1 protein (Fig. 5g) and downregulation of PGK1 ubiquitination (Fig. 5h)."
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"Together, these findings suggest that the ADRM1/UCH37 axis is involved in the regulatory effect of pro-SFTPB on the ubiquitination of PGK1 in NSCLC."
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"Importantly, we found colocalization of ADRM1 and PGK1 (Fig. 5d), and silencing of ADRM1 or UCH37 decreased PGK1 protein levels (Fig. 5e) and increased PGK1 ubiquitination in NSCLC cells (Fig. 5f), suggesting that the ADRM1/UCH37 axis is involved in the regulation of PGK1 deubiquitination."
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