IndraLab

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"XREF_BIBR In addition, alpha-melanocyte-stimulating hormone (a-MSH), ligand of the melanocortin 1 receptor (MC1R), not only induces melanin synthesis but has also an ability to reduce UVB induced DNA damage by enhanced nucleotide excision repair (NER) in melanocytes, therefore directly influencing UV resistance."

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"Melanotropic peptides such as a-melanocyte-stimulating hormone (a-MSH) induce formation and release of melanin pigment in B16-F1 cells."

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"XREF_BIBR In the recent study by Hur, XREF_BIBR luteolin did not inhibit tyrosinase activation directly, but it concentration-dependently inhibited tyrosinase activation and melanin generation increase by a-MSH in the B16 melanoma cell as well as cAMP generation by MSH and forskolin, which identified the action mechanism of its whitening action generation."