IndraLab

Statements

IKK_complex phosphorylates CYLD on S432. 3 / 3
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sparser
"These results support the notion that phosphorylation of CYLD by IKK at Ser432 and Ser436 is associated with β-TRCP-mediated poly-ubiquitination and subsequent degradation of CYLD."
24961988
reach
"These results support the notion that phosphorylation of CYLD by IKK at Ser432 and Ser436 is associated with beta-TRCP-mediated poly-ubiquitination and subsequent degradation of CYLD."
24961988
rlimsp
"In further support of this finding, mutating Ser432 and Ser436 to Alanine abolished IKK-dependent, β-TRCP-mediated poly-ubiquitination of CYLD in 293T cells (Figure 3H). Together, these results demonstrate that IKK-mediated phosphorylation of Ser432 and Ser436 might play a pivotal role in triggering SCFβ-TRCP-dependent CYLD poly-ubiquitination."
24961988