IndraLab

Statements

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"Proliferation inhibition by loss of USP10 depends on SKP2 functional status."
31044085
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"HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway."
35277183
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"Interesting, Spautin‐1 imposed minimal effect on the cell proliferation (Fig. S5C), suggesting that under our experimental conditions, USP10 mainly modulated cell migration rather than cell proliferation, through the regulatory effect on Smad4."
31721429
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"USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer."
30604502
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"We found that loss of USP10 consequently suppressed the proliferation of CML cells and induced G0/G1 phase arrest in all CML cell lines examined, suggesting that USP10 is critical to CML cell proliferation."
31044085
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"Targeting USP10 by shRNA inhibited CRC proliferation and metastasis, and this effect was reversed by overexpression of NLRP7."
33838681
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"As shown in XREF_FIG, downregulation of USP10 increased cancer cell proliferation in p53 +/+ cells, while USP10 expression levels have no apparent effect on proliferation in cells lacking p53."
20096447
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"Moreover, inhibition of USP10 significantly suppresses the proliferation of both imatinib sensitive and imatinib resistant CML cells, which likely depends on SKP2 status."
31044085
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"Paradoxically, USP10 could promote cancer cell proliferation in mutant p53 background."
20096447
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"Moreover, we have also experimentally demonstrated that both pharmacological and genetic inhibition of USP10 are capable of, in a SKP2-depednet manner, suppressing the proliferation of both IM sensitive and IM resistant CML cells in cell cultures and in mouse xenograft models."
31044085
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"Two independent USP10 short hairpin RNAs (shRNAs) both promoted cell proliferation of HCCLM3 and HUH7 cells."
30056112
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"In vitro data showed that USP10 deficiency reduced proliferation and migration of rat thoracic aorta smooth muscle cells (A7r5) and human aortic smooth muscle cells (HASMCs)."
34599966
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"Indeed, downregulation of USP10 decreases p53 stability and increases cancer cell proliferation XREF_BIBR, thus projecting a role as a tumor suppressor."
21283576
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"In conclusion, these results suggest that USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
30281322
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"USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
30281322
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"For example, in hepatocellular carcinoma, Zhu et al. reported that USP10 promotes proliferation [XREF_BIBR], whereas Lu et al. found that USP10 suppresses tumor progression by inhibiting mTOR activation [XREF_BIBR]."
33838681
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"Specifically, USP10 activates PTEN by preventing its K63 linked polyubiquitination mediated by TRIM25 and suppresses the AKT and mTOR signaling pathway thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."
34416231
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"USP10 overexpression promoted ectopic endometrial stromal cell migration and proliferation, suppressed cell apoptosis, and activated MEK and ERK signaling that is a critical downstream target of the serine/threonine protein kinase Raf-1, which was significantly blocked by PD98059."
30281322
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"For example, in p53-mutant RCC cells, increased USP10 expression promotes cell proliferation via deubiquitinating and stabilizing the mutant p53 [27]."
35627217
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"In RCC cell lines that have mutant p53, USP10 promotes cancer cell proliferation, and downregulation of USP10 would be beneficial for the inhibition of cancer growth."
20932800