IndraLab

Statements

reach
"These findings indicated that USP10 promoted cell proliferation via regulation of cell cycle progression and migration in both treatments with and without PDGF-BB but did not trigger cell apoptosis."
34599966
reach
"USP10 promoted the proliferation of PDAC both in vitro and in vivo."
37757903
reach
"Functionally, USP10 serving as an oncogene potentiates the proliferation and metastasis of HNSCC cells in vitro and in vivo."
40204721
reach
"Indeed, downregulation of USP10 decreases p53 stability and increases cancer cell proliferation XREF_BIBR, thus projecting a role as a tumor suppressor."
21283576
reach
"For example, in hepatocellular carcinoma, Zhu et al. reported that USP10 promotes proliferation [XREF_BIBR], whereas Lu et al. found that USP10 suppresses tumor progression by inhibiting mTOR activation [XREF_BIBR]."
33838681
reach
"Targeting USP10 by shRNA inhibited CRC proliferation and metastasis, and this effect was reversed by overexpression of NLRP7."
33838681
reach
"USP10 overexpression promoted ectopic endometrial stromal cell migration and proliferation, suppressed cell apoptosis, and activated MEK and ERK signaling that is a critical downstream target of the serine/threonine protein kinase Raf-1, which was significantly blocked by PD98059."
30281322
reach
"Our results indicate that spautin-1 as well as knockdown of its downstream targets, USP10 and USP13, reduced the proliferation and migration of glioblastoma cells."
38857836
reach
"In conclusion, these results suggest that USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
30281322
reach
"USP10 promotes CRC proliferation, oxaliplatin resistance, and DNA damage repair by stabilising XAB2."
40069750
reach
"Paradoxically, USP10 could promote cancer cell proliferation in mutant p53 background."
20096447
reach
"Subsequently, the transcription and protein expression of PHGDH, PSAT1, and PSPH (Figure 2A,C), which are pivotal enzymes in SSP, was increased after USP10 knockdown, suggesting that USP10 loss can promote serine synthesis in HCC.To further explore the role of serine in promoting HCC proliferation by USP10, we constructed a serine deletion model in USP10 knockdown cell lines."
39327097
reach
"In a recent study, we showed that USP10 triggered the proliferation in chronic myeloid leukemia."
34599966
reach
"USP10 knockdown decreased the proliferation of CRC cells in vitro, an effect that was reversed by the XAB2 (Fig. 11A-C)."
40069750
reach
"As shown in XREF_FIG, downregulation of USP10 increased cancer cell proliferation in p53 +/+ cells, while USP10 expression levels have no apparent effect on proliferation in cells lacking p53."
20096447
reach
"USP10 promotes cell proliferation, migration, and invasion in NSCLC through deubiquitination and stabilization of EIF4G1."
39390016
reach
"12 Recent research has suggested that USP10 modulates cell proliferation, migration, and apoptosis."
37184153
reach
"Overall, these findings suggest that USP10 promotes cell proliferation, oxaliplatin resistance, and DNA damage repair in CRC by stabilising XAB2."
40069750
reach
"In addition to prostate cancer, USP10 also promotes the proliferation of hepatocellular carcinoma as a Dub and a stabilizer of the oncogenic transcription factor Yes-associated protein/transcriptional coactivator with PDZ-binding motif (28)."
34416231
reach
"Moreover, inhibition of USP10 significantly suppresses the proliferation of both imatinib sensitive and imatinib resistant CML cells, which likely depends on SKP2 status."
31044085
reach
"For instance, USP10 depletion was reported to inhibit proliferation of HCC by impairing the YAP/TAZ pathway (34)."
36840458
reach
"In addition, CCK8 assays confirmed that USP10 knockdown inhibited the proliferation of U2‐OS and 143B cells (Figure 7B)."
37184153
reach
"However, other studies have reported that USP10 overexpression promotes tumor metastasis or proliferation in adult T cell leukemia, 40 glioblastoma multiforme, 41 chronic myeloid leukemia, 42 non‐small‐cell lung cancer, 43 and liver cancer."
39327097
reach
"Moreover, we have also experimentally demonstrated that both pharmacological and genetic inhibition of USP10 are capable of, in a SKP2-depednet manner, suppressing the proliferation of both IM sensitive and IM resistant CML cells in cell cultures and in mouse xenograft models."
31044085
reach
"Functional assays confirmed that USP10 could potentiate HNSCC cell proliferation and metastatic capacities in vitro and in vivo."
40204721
reach
"For instance, USP10 functions as a DUB of YAP/TAZ and drives the proliferation of hepatocellular carcinoma via stabilizing the YAP/TAZ complex [18]."
40204721
reach
"We found that loss of USP10 consequently suppressed the proliferation of CML cells and induced G0/G1 phase arrest in all CML cell lines examined, suggesting that USP10 is critical to CML cell proliferation."
31044085
reach
"Proliferation inhibition by loss of USP10 depends on SKP2 functional status."
31044085
reach
"This stabilizing action enhances FLT3 downstream signaling, promoting cell proliferation and survival, and thus highlighting USP10′s potential as a therapeutic target in FLT3-driven leukemias.In breas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37863330
reach
"USP10 knockdown decreased the proliferation, migration, and invasion in NSCLC cells, which were rescued by EIF4G1overexpression."
39390016
reach
"For example, USP10 could enhance the proliferation and metastasis of NSCLC by stabilizing HDAC744, whereas USP10 can stabilize p53 and inhibit breast cancer progression 45."
37786443
reach
"These collective findings align to indicate that D1 's effectiveness in driving Huh-7 cell apoptosis is closely linked to its ability to induce S-phase arrest, thereby underscoring its potential in mo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38718626
reach
"Based on the SKP2 status in CML, USP10 inhibition significantly reduced the imatinib-sensitive and imatinib-resistant CML cell proliferation (71)."
38559562
reach
"The overexpression of USP10 promoted the proliferation of MCF-7 cells ( Fig. 3 c-d )."
37863330
reach
"USP10 has been reported to promote cell proliferation of hepatocellular carcinoma via deubiquitinating and stabilizing YAP/TAZ [29]; USP10 suppresses the growth and invasive capacity of lung cancer cells by overexpressing PTEN [30]; USP10 modulates oncogene-induced senescence through deubiquitination and stabilization of p14ARF [31]; USP10 propels cell proliferation in colon cancer through deubiquitinating and stabilizing Musashi-2 [32]."
35791074
reach
"Two independent USP10 short hairpin RNAs (shRNAs) both promoted cell proliferation of HCCLM3 and HUH7 cells."
30056112
reach
"Specifically, USP10 has been shown to promote hepatocellular carcinoma proliferation by deubiquitinating and stabilizing YAP/TAZ [ 20 ], enhance the progression of esophageal squamous cell carcinoma b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38364962
reach
"USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer."
30604502
reach
"USP10 knockdown increased ubiquitination and degradation of YAP1, which further decreased the programmed cell death ligand 1 (PD-L1) and Galectin-9 expression, suppressed immune escape, and reduced the proliferation and metastasis of PAAD cells in vitro and in vivo."
35271750
reach
"Among these DUBs, OTUB1, and USP10 significantly enhanced cell proliferation and invasion (Figure 2A,B, Figure S2A)."
37986681
reach
"To sum up, USP10 contributes to proliferation and migration of HCC cells.According to an emerging study, deubiquitinating enzyme USP10 pushes HCC metastasis by deubiquitinating and stabilizing Smad4 p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34914965
reach
"USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway."
30281322
reach
"USP10 can promote the proliferation of PCa cells and play an oncogenic role."
36811009
reach
"Increased USP10 expression in mutant p53 background increases p53 levels and promotes cancer cell proliferation, while downregulation of USP10 inhibits cancer cell growth."
25444757
reach
"In vitro data showed that USP10 deficiency reduced proliferation and migration of rat thoracic aorta smooth muscle cells (A7r5) and human aortic smooth muscle cells (HASMCs)."
34599966
reach
"In RCC cell lines that have mutant p53, USP10 promotes cancer cell proliferation, and downregulation of USP10 would be beneficial for the inhibition of cancer growth."
20932800
reach
"In contrast, one study showed that USP10 enhanced CRC cell proliferation by stabilizing MSI2, an oncogenic factor.Vismodegib, a drug used for treating basal cell carcinoma, has been shown to decrease the activity of two DUBs, USP25 and USP28, as well as the levels of their substrates, such as c-MYC, in CRC cells[30]."
38292842
reach
"Zhu et al. showed that USP10 promotes the proliferation of hepatocellular cancer by deubiquitinating YAP/TAZ."
37664607
reach
"These research findings are similar to our findings, indicating that USP10 can promote cell proliferation and inhibit apoptosis to enhance tumor cell resistance to platinum-based drugs.In summary, our[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38364962
reach
"Furthermore, knockdown of USP10 expression inhibited PDAC cell proliferation and migration in vivo and in vitro ."
39430239
reach
"HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway."
35277183
reach
"Interestingly, USP10 overexpression promotes an increase in Raf1 protein levels through deubiquitylation to promote the proliferation and migration of endometrial stromal cells (36)."
34688658
reach
"Consistent with the previous finding that USP10 promotes proliferation of colon cancer cells [ 29 ], the present study also uncovered that USP10 played an oncogenic role in HCC cell growth.Referring t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34914965
reach
"USP10 inhibition or knockdown suppresses VSMCs proliferation in vitro."
34599966
reach
"For example, in p53-mutant RCC cells, increased USP10 expression promotes cell proliferation via deubiquitinating and stabilizing the mutant p53 [27]."
35627217
reach
"Moreover, flow cytometry analysis indicated that USP10 deletion inhibited BrdU incorporation into cells, suggesting that USP10 inhibition/knockdown induced cell proliferation inhibition (Fig. 2, I–L)."
34599966
reach
"Interesting, Spautin‐1 imposed minimal effect on the cell proliferation (Fig. S5C), suggesting that under our experimental conditions, USP10 mainly modulated cell migration rather than cell proliferation, through the regulatory effect on Smad4."
31721429
reach
"Depletion of the human homolog of UBP3, USP10, impairs proliferation of aneuploid human cells."
27807036
reach
"Additionally, it has been observed that USP10 enhances the proliferation of cancer cells in the presence of TP53 mutations [95]."
38785979
reach
"Finally, USP10 inhibition also inhibits the proliferation of stable aneuploid cells; mouse embryonic fibroblasts (MEFs) trisomic for chromosome 13 or 16 were more sensitive to spautin-1 treatment than their euploid counterparts (Fig. 7D)."
27807036