IndraLab

Statements

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"In our study, the expression of MALAT1, USP3-AS1, and LINC-PINT was associated with worse overall survival in breast cancer patients."
33495450
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"The PRL and SOX4 protein-coding genes are associated with CASC15 , PPP1R26 is associated with PPP1R26-AS1 , and USP3 and FBXL22 are associated with USP3-AS1 ."
31920530
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"In conclusion, USP3-AS1 is a novel promoter of CRLM by inducing histone lactylation."
39837984
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"Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation."
39837984
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"We found that USP3-AS1 was significantly upregulated in CRLM-derived PDOs compared to primary tumors."
39837984
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"High level of USP3-AS1 was positively associated with postoperative liver metastasis and negatively correlated with the prognosis of colorectal cancer (CRC) patients."
39837984
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"Overexpression of USP3-AS1 significantly enhanced both sphere formation efficiency and liver metastasis in PDOs."
39837984
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"Gene set enrichment analysis revealed that USP3-AS1 upregulation significantly enriched glycolysis and MYC signaling pathways."
39837984
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"Metabolomics analysis confirmed that USP3-AS1 promoted glycolysis in PDOs, whereas glycolysis inhibition partially attenuated the effects of USP3-AS1 overexpression on PDO growth and liver metastasis."
39837984
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"We revealed that USP3-AS1 stabilized MYC via post-translational deubiquitination, thereby promoting glycolysis."
39837984
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"We demonstrated that USP3-AS1 increased the stability of USP3 mRNA, resulting in higher USP3 protein expression."
39837984
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"In addition, VIM-AS1 promoted keratinocyte proliferation, whereas SMAD5-AS1, USP3-AS1, LINC02035, and STARD4-AS1 mediated the opposite effect."
38468869
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"Interestingly, lncRNA profiling of MALAT1-depleted TNBC also revealed a number of altered lncRNAs in response to MALAT1 deletion, suggesting a reciprocal relationship between MALAT1 and a number of lncRNAs, including NEAT1, USP3-AS1, and LINC-PINT, in TNBC."
33495450
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"Elevated expression of MALAT1, USP3-AS1, and LINC-PINT correlated with worse clinical outcomes in BC patients."
33495450
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"After this cross-sectional study, we were able to identify three significant lncRNAs, CASC15 , PPP1R26-AS1 , and USP3-AS1 , which could serve as potential biomarkers in clinical studies of neuroblastoma pathogenesis."
31920530
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"Of these, RFPL1S ( p = 0.0001), PPP1R26-AS1 ( p = 0.03), RP11-439E19.3 ( p = 1.24 × 10 –6 ), CASC15 ( p = 1.6 × 10 –7 ), AC004540.5 ( p = 0.0002), and CTD-2881E23.2 ( p = 1.6 × 10 –9 ) were found to be significantly upregulated ( xref ), while USP3-AS1 ( p = 1.78 × 10 –6 ), CHRM3-AS2 ( p = 0.003) and RP6-99M1.2 ( p = 0.002) were significantly downregulated ( xref )."
31920530
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"Smooth muscle antisense RNA1 ( ACTA2-AS1 ), ubiquitin specific peptidase 3 antisense RNA1 ( USP3-AS1 ), protein tyrosine phosphatase receptor G-type antisense RNA1 ( PTPRG-AS1 ), small nucleolar RNA host gene 14 ( SNHG14 ), PTOV1 extended AT hook containing adapter protein antisense RNA1 ( PTOV1-AS1 ), tumor protein translation control 1 antisense RNA1 ( TPT1-AS1 ), SH3 domain binding protein 5 antisense RNA1 ( SH3BP5-AS1 )."
39529075
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"Interestingly, the expression of MALAT1, USP3-AS1, and LINC-PINT was associated with worse overall survival in breast cancer patients (Fig. xref )."
33495450
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"This database revealed that the expression of three lncRNAs was altered significantly in neuroblastoma samples; two were upregulated, namely CASC15 ( p < 0.0001, unpaired two-tailed t -test with Welch’s correction) and PPP1R26-AS1 ( p < 0.05, unpaired two-tailed t -test with Welch’s correction), and one was downregulated, USP3-AS1 ( p < 0.0001, unpaired two-tailed t -test with Welch’s correction) ( xref )."
31920530
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"They reported up-regulation of RFPL1S, PPP1R26-AS1, RP11-439E19.3, CASC15, AC004540.5, and CTD-2881E23.2 while down-regulation of USP3-AS1, CHRM3-AS2 and RP6-99M1.2 in tumor cells compared with the corresponding non-tumor mononuclear cells isolated from bone marrow (MNCs)."
33718173
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"They suggested CASC15, PPP1R26-AS1, and USP3-AS1 lncRNAs as putative markers in clinical investigations in this type of pediatric cancer ( xref )."
33718173
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"Moreover, the downregulation of SMAD5-AS1, USP3-AS1, LINC02035, and STARD4-AS1 enhanced the proliferation of keratinocytes, whereas the knockdown of VIM-AS1 inhibited keratinocyte viability ( xref )."
38468869
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"Of these, one was upregulated, PPP1R26-AS1 ( p = 5.2 × 10 –4 , number of samples with high expression = 14, number of samples with low expression = 74), and the other was downregulated, USP3-AS1 ( p = 0.019, number of samples with high expression = 42, number of samples with low expression = 46) ( xref )."
31920530
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"The RT-qPCR test results showed that the expression trends of lncRNAs ACTA2-AS1 , USP3-AS1 , PTPRG-AS1 , SNHG14 , TPT1-AS1 , and PTOV1-AS1 were consistent with the sequencing results."
39529075
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"By sequencing analysis, only 20 lncRNAs with significant differential expression trends were found, of which 17 were significantly upregulated and three significantly downregulated, including TSIX , ACTA2-AS1 , and USP3-AS1 ."
39529075
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"We have identified five lncRNA-associated coding partners that are near (around the 5 kb region) to cross-validated lncRNAs CASC15, PPP1R26-AS1 , and USP3-AS1 , which belong to different classes/biotypes of lncRNAs."
31920530
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"Recently, through RNA-seq dataset on neuroblastoma identified three significant lncRNAs, CASC15, PPP1R26-AS1, and USP3-AS1, which could serve as potential biomarkers in clinical studies of neuroblasto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34302945
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"USP3-AS1 has also been reported as a potential biomarker for neuroblastoma pathogenesis studies xref ."
33495450
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"Interestingly, the PPP1R26-AS1- associated gene PPP1R26 was differentially expressed in all of the conditions [Tumor vs. MNCs, DTCs vs. MNCs, and DTCs (relapsed) vs. MNCs (relapsed)], whereas USP3-AS1 -associated coding genes USP3 and FBXL22 were differentially expressed only in primary neuroblastoma tumor."
31920530
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"After cross-sectional analysis, three lncRNAs, CASC15 , PPP1R26-AS1 and USP3-AS1 , were found to be significantly altered in different datasets compared to other lncRNAs ( xref )."
31920530
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"However, the association or any functional analysis of the third of the identified lncRNAs, USP3-AS1 , has not been reported with any cancer."
31920530
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"Pathway analysis (Fig.  xref A, Table S8) also identified networks of significant lncRNA genes (HCP5, NEAT1, USP3-AS1, AATBC, CASC8, PDCD4-AS1, NRIR) affecting metabolism, CVD, and ophthalmic disease among other networks."
38849833
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"Three of these lncRNA candidates, USP3-AS1 , LINC00877 , and AC009312 .1, were validated to have reduced expression in metastatic compared to non-metastatic PCPGs."
34536193
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"The generalized linear model identified three miRNAs ( miR-182 , miR-183 , and miR-383 ) and six lncRNAs ( MAGI2-AS3 , LINC00877 , TMEM220-AS1 , USP3-AS1 , AC009312.1 , and HIST2H2BF ) to be associated with aggressive or metastatic status ( xref )."
34536193
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"Of the six lncRNAs, we identified significantly lower expression of five lncRNAs ( MAGI2-AS3 , LINC00877 , AC009312.1 , USP3-AS1 , and HIST2H2BF ) in aggressive or metastatic PCPGs in the TCGA cohort."
34536193
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"The under expression of the lncRNAs LINC00877 , AC009312.1 , and USP3-AS1 in metastatic compared to non-metastatic PCPGs was confirmed by the qRT-PCR in an independent cohort of PCPG tumor samples ( xref – xref )."
34536193
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"The target genes that had significant positive correlation (Pearson’s correlation coefficient >0.33, p value < 0.01) with the expression of the lncRNAs MAGI2-AS3 , LINC00877 , AC009312.1 , USP3-AS1 , and HIST2H2BF were retained as the most probable candidate genes that are related to the “sponge” function of these lncRNAs (see xref )."
34536193
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"We checked the association of metastasis-free survival with four miRNAs ( miR-183 , miR-182 , miR-96 , and miR-383 ) and five lncRNAs ( MAGI2-AS3 , LINC00877 , AC009312.1 , USP3-AS1 , and HIST2H2BF ) shortlisted from the previous analysis (see above), using the univariate Kaplan–Meier analysis."
34536193
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"In this multivariate model we included the lncRNAs MAGI2-AS3 and LINC00877 that were identified from univariate analysis, lncRNA USP3-AS1 and AC009312.1 that were identified to be elevated in metastatic PCPGs from qRT-PCR validation, and miRNAs miR-182 , miR-183 , miR-383 and miR-96 that were identified from the univariate analysis, as well as identified to be elevated in metastatic PCPGs from qRT-PCR validation."
34536193
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"We developed a risk-score model comprising the expression profiles of the important miRNAs ( miR-182 , miR-183 , miR-96 , and miR-383 ) and lincRNAs ( LINC00877 , AC009312.1 , MAGI2-AS3 , USP3-AS1 , and HIF1A-AS2 ) and important clinical parameters related to metastatic potential (germline SDHB mutation, somatic ATRX mutation, extra-adrenal tumor location, hormone secretory type) that have been previously established in the literature."
34536193
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"When we tested their expression signature with qRT-PCR in independent patient samples, we validated that three of these lncRNAs, LINC00877 , AC009312.1 , and USP3-AS1 , were downregulated in metastatic PCPGs compared to non-metastatic PCPGs."
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