IndraLab

Statements

USP1 inhibits DDR. 2 / 2
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"Other USP1 activities include involvement in a feedback loop to limit DDR CHK1 protein kinase activity , and the regulation of cellular differentiation in osteosarcoma cells by deubiquitylating and hence affecting the stability of inhibitors of DNA-binding proteins ."
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"As DDR markers are highly elevated in human and rodent diabetic islets/β-cells in vitro and in vivo and correlate with β-cell death (Belgardt et al., 2015, Himpe et al., 2016, Nyblom et al., 2009, Oleson et al., 2014, Oleson et al., 2016, Tornovsky-Babeay et al., 2014), we sought to determine whether USP1 inhibition would modulate DDR under diabetic conditions."
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