IndraLab

Statements

USP7 increases the amount of IL18. 3 / 3
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reach
"Consistently, upregulation of USP7 enhanced pyroptosis, IL-1β and IL-18 levels, MMP-1, MMP13, and NLRP3 inflammasome activation via upregulation of ROS levels in rat chondrocytes."
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"The overexpression of USP7 enhanced pyroptosis, ROS production, interleukin (IL)-1beta and IL-18 levels, and the expression level of NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, matrix metalloproteinases (MMP) 1, and MMP13, which was abolished by ROS inhibition."
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"ELISA and Western blotting results indicated that USP7 overexpression significantly increased IL-1beta and IL-18 levels as well as the expression of USP7, NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, MMP1, and MMP13, which was decreased by USP7 KD or apocynin (XREF_FIG)."
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