IndraLab

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Gag activates SCN5A. 4 / 4
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"In contrast, beta 1 -like effects on hH1 currents were observed when coexpressing the opposite chimera beta 211, indicating that the MA plus the ID of the beta 1 subunit are required to modulate hH1 channels (XREF_FIG, XREF_TABLE)."
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"This result shows that the beta 1 MA is required in beta 11Delta to modulate hH1 channels."
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"In conclusion, the cardiac Na + channel isoform hH1 is modulated by the beta 1 MA plus the ID, whereas the beta 1 ED was sufficient to modulate the neuronal isoform IIA."
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"Similar results were obtained with a deletion mutant consisting of the beta 2 ED plus the beta 1 MA (beta 21Delta, XREF_FIG, XREF_TABLE), confirming that the beta 1 MA is not sufficient to modulate hH1 currents."
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