IndraLab

Statements


USP30 is phosphorylated. 5 / 5
| 5

sparser
"Moreover, IKKβ-induced USP30 phosphorylation and stabilization promote tumor growth and development in the dimethylnitrosamine (DEN)-/CCL4-induced model of HCC ( xref )."

sparser
"IKKβ phosphorylated and stabilized USP30, which promoted USP30 to deubiquitinate ATP citrate lyase (ACLY) and fatty acid synthase (FASN)."

sparser
"Firstly, USP30 was phosphorylated in human hepatocellular carcinoma (HCC)."

sparser
"USP30 hydrolyses phosphorylated ubiquitin-KG-TAMRA with ~8-fold lower efficiency ( xref , xref ), and phosphorylation of monoubiquitinated inactive USP30 consistently impaired deubiquitination by active USP30 ( xref , xref )."

sparser
"In HCC, the IκB kinase (IKKβ) phosphorylated and stabilized USP30, which promoted USP30 to deubiquitinate the critical lipogenesis-related enzyme-ATP citrate lyase (ACLY) ( xref ; xref ), and prompted the development of HCC ( xref )."