IndraLab

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"In vitro, USP7 knockdown promoted HUVEC proliferation, migration, and angiogenesis by inducing M2 macrophage polarization and inhibiting M1 macrophage polarization under HG condition."
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"Meanwhile, the abrogation of USP7 suppressed GC cell proliferation by stabilizing p53 and promoting cell cycle arrest both in vitro and in vivo."
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"Overall, these data indicated that USP7 was overexpressed in GC and that USP7 overexpression may contribute to the poor survival outcome of GC patients.3.2 Abrogation of USP7 suppressed GC cell proliferation and cell cycle progression."
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"Of note, USP47 KO did not affect cell proliferation, while USP7/USP47 DKO led to reduced cell proliferation (Supplemental Fig. S3A,B)."
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"The results of Cell Counting Kit-8 and 5-ethynyl-20-deoxyuridine assays showed that the viability and proliferation of FGSCs were negatively regulated by Usp7."
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"Silencing of KDM6B reversed the promoting effect on autophagy and proliferation induced by overexpression of USP7."
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"The USP7 selective small-molecule inhibitors P5091 and P22077 inhibited cell proliferation and induced megakaryocytic differentiation in both cell lines and primary cells."
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"Combinatory inhibition of EZH2 and USP7 synergistically induces proliferation defect at relatively low concentrations (0.08 μM), which suggests a new therapeutic approach by co-targeting EZH2 and USP7 for DLBCL patients.Ubiquitously expressed genes USP7 and STAT3 were emergently marked by H3K27me3."
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"In colon carcinoma cells, on the other hand, and in line with our observation, USP7 overexpression led to a reduced proliferation, which was attributed to an altered regulation of p53 and Mdm2 [35]."
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"In vitro and in vivo functional rescue experiments showed that overexpression of SNAI2 reversed the inhibitory effects on proliferation and metastasis caused by USP7 depletion."
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"By thermal shift assay, the same authors demonstrated that UA interacts with USP7 in MM cell lines.UA dose-dependently inhibited the proliferation of the MM with an IC50 of 6.56 μmol/L, accompanied by reductions in USP7 substrates such as MDM2, UHRF1 and DNMT1."
36771100
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"Overall, these results suggested that the abrogation of USP7 can restrict the proliferation of tumor cells in vivo.4 Discussion."
40061891
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"USP7 inhibits LUAD cell proliferation via modulation of the ERK1/2 signaling pathway."
35948545
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"In contrast, silencing USP7 significantly inhibit the cell proliferation process."
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"These results indicate that USP7 overexpression inhibits lung cancer cell proliferation and migration."
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"It is likely that HAP1 cells have active p53 signaling , so inactivation of USP7 would inhibit proliferation of HAP1 cells through stabilization of p53."
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"Collectively, these results indicate that overexpression of USP7 inhibits LUAD cell proliferation by suppressing the ERK1/2 signaling pathway in a p53-independent manner."
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"Overexpression of Usp7 increased, while Usp7-CA decreased the proliferation of D283 cells ( Fig. 1 D)."
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"In a nutshell, pharmacological and genetic abrogation of USP7 can inhibit the proliferation of MKN45 cells both in vitro and in vivo, which indicates that USP7 can be considered as a promising therapeutic target for the treatment of gastric cancer."
40061891
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"The decreased proliferation of Daoy cells caused by usp7 knockout could totally restored by Usp7 overexpression ( Fig. 2 F and G)."
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"Similarly, upregulation of USP7 can inhibit the proliferation of esophagus cancer cells, indicating its tumor suppressing roles [XREF_BIBR]."
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"A previous study XREF_BIBR showed that USP7 transcriptional activation by FOXO6 suppresses lung cancer progression and that USP7 inhibited cell proliferation in EC."
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"The observation that loss of usp7 blocking MB cell proliferation and migration suggests that Usp7 may activates an oncogenic pathway in this system."
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"Taken together, we deduce that USP7 suppresses LUAD cell proliferation."
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"Aberrant expression of USP7 decreases Foxp3 polyubiquitination, allowing Treg cell-mediated proliferation and tumor growth."
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"Through EdU and RTCA assays, our study also demonstrated that the overexpression of p57 KIP2 significantly repressed the proliferation capabilities of 8505c cells, whereas the overexpression of USP7 r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP7 promotes the growth of non-small cell lung cancer cells by stabilizing Ki-67 protein, while metformin can inhibit the proliferation of esophageal cancer by upregulating USP7, suggesting that USP7 plays different roles in different types of tumors [50-52], USP4 and USP15 can stabilize TGF-β receptors and increase TGF-β-mediated EMT, leading to metastasis of hepatocellular carcinoma and glioblastoma [53-55]."
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"Specific silencing of USP7 using siRNA or USP7 inhibitors led to phenotypical and functional changes in M2 MPhis, favoring CD8 + T cells proliferation in vitro."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"Beyond our proven hypothesis that Usp7 RNAi inhibited cell proliferation and differentiation of the regenerative worms, we wondered how cell apoptosis would be affected by Usp7 deficiency during regeneration."
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"The proliferation rate of HUVECs was significantly suppressed by the overexpression of USP7 but rescued by the inhibition of p53 ( Figure 4C; P<0.05)."
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"Furthermore, early studies in human colon cancer xenograft models showed that downregulation of USP7 suppresses cell proliferation and delays tumor growth due to p53 stabilization in the absence of ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, to the best of our knowledge, no studies have evaluated the mechanism and function of Usp7 in determining FGSC self-renewal and differentiation.In this paper, we report for the first time that Usp7 inhibited the proliferation of FGSCs and promoted their differentiation via genomic methylation."
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"The results showed that the overexpression of Usp7 in FGSCs significantly inhibited their proliferation compared with that of controls (Fig. 4d, e)."
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"In addition, inhibition of USP7 by its inhibitor reduced cell proliferation due to p53 stabilization in gastric cancer cells (129)."
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"Importantly, in the absence of stress, both HAUSP up and downregulation inhibit cell proliferation in vitro and tumor growth in vivo due to constitutively elevated p53 levels."
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"The soft agar colony formation experiment displayed that silencing of USP7 promoted the 786-O cells ' proliferation compared to the unprocessed group, and the difference between these two groups was, respectively, statistically significant (P =.0006, P =.0004)."
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"Intervention in USP7 to induce the downregulation of Ki-67 protein could inhibit proliferation of NSCLC cells and even increase the sensitivity of the cells to some chemotherapy drugs."
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"To explore whether abrogation of USP7 can suppress GC cell proliferation, knockout of USP7 in MGC-803 was applied."
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"In addition, we found that USP7 depleted cells transfected with exogenous ARMC5 fully prevented the cell proliferation using the CCK-8 assay."
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"In vitro studies also showed that downregulation of USP7 reduced proliferation of MHCC97-H cell lines and upregulation increased proliferation of Huh7 and Hep3B cell lines, suggesting that USP7 promoted HCC progression.31 Wang et al.70 performed wound healing assay and cell invasion assay to show that overexpression of USP7 can enhance invasion of HCC cells, while USP7-knockdown can suppress HCC invasion."
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"In addition, cell proliferation was reduced 2- to 3-fold by HAUSP or nucleolin depletion, respectively (XREF_FIG), and we observed a ~ 4 fold decrease in proliferation after HAUSP and nucleolin double-knockdown (XREF_FIG)."
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"Hence, abrogation of USP7 inhibits proliferation of GC cells through promoting the stability of P53."
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"The result showed that cell proliferation was inhibited by the knockdown of nucleolin, HAUSP, and nucleolin and HAUSP double-knockdown, respectively (XREF_FIG)."
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"Knockdown of USP7 inhibits proliferation of ovarian cancer cells."
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"Precise regulation of USP7 expression and activity is therefore necessary for maintaining proper cell proliferation, and both up- and downregulation of USP7 inhibit colon cancer cell proliferation (Be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of USP7 led to NOTCH1 degradation and suppressed T-ALL cell proliferation in vitro and in vivo."
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"Hence, we demonstrate that abrogation of USP7 can suppress GC cells proliferation via stabilizing P53 invitro and invivo."
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"Moreover, USP7 knockdown in PDAC cells also suppressed TOPFlash luciferase activity (Fig. 5f), cell proliferation activity (Fig. 5g) and invasive potential (Fig. 5h)."
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"Under insufficient glucose availability, the level of USP7 is inhibited by p53, resulting in degradation of PRMT1 via ubiquitination of the proteasome pathway, thereby inhibiting the Warburg effect and proliferation of NSCLC cells."
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"Specifically, gene set 1 and gene set 2 comprised a list of genes known to promote drug resistance, cell proliferation, metastasis and to prevent tumor apoptosis, including CROT [ 54 ] and USP7 [ 55 ,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"101 HAUSP expression is enhanced by FoxO6, which inhibits proliferation of lung carcinoma."
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"Overexpression of USP7 can regulate ERK1/2 signaling pathway, increase P53 expression, and inhibit G2/M transformation and proliferation of LUAD cells by deubiquitinating the M1, K6, K11, K27, K33, and K48 polyubiquitin chains of Raf-1 to reduce the level of RAF1 phosphorylation (7)."
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"Importantly, abrogation of USP7 not only sensitizes GC cells to T cell mediated killing by downregulating cell surface PD-L1 levels and attenuating its interaction with PD-1, but also suppresses the proliferation of GC cells by stabilizing P53 invitro and invivo."
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"42 It has also been shown that both up or down-regulation of USP7 protein expression reduces cell proliferation in colon cancer and tumour development in vivo, as a consequence of increasing p53 levels.43Interleukin-6 (IL-6) stimulates STAT3 activation in normal physiological conditions and is controlled via negative feedback mechanisms."
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"The following is/are the supplementary data related to this article : 3.5 Abrogation of USP7 suppressed GC cell proliferation and cell cycle progression."
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"USP7 expression is also enhanced by FOXO6, which inhibits proliferation of lung carcinoma [XREF_BIBR]."
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