IndraLab

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"In addition, cell proliferation was reduced 2- to 3-fold by HAUSP or nucleolin depletion, respectively (XREF_FIG), and we observed a ~ 4 fold decrease in proliferation after HAUSP and nucleolin double-knockdown (XREF_FIG)."
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"It is likely that HAP1 cells have active p53 signaling , so inactivation of USP7 would inhibit proliferation of HAP1 cells through stabilization of p53."
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"In contrast, silencing USP7 significantly inhibit the cell proliferation process."
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"Inhibition of USP7 led to NOTCH1 degradation and suppressed T-ALL cell proliferation in vitro and in vivo."
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"The USP7 selective small-molecule inhibitors P5091 and P22077 inhibited cell proliferation and induced megakaryocytic differentiation in both cell lines and primary cells."
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"101 HAUSP expression is enhanced by FoxO6, which inhibits proliferation of lung carcinoma."
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"Similarly, upregulation of USP7 can inhibit the proliferation of esophagus cancer cells, indicating its tumor suppressing roles [XREF_BIBR]."
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"The soft agar colony formation experiment displayed that silencing of USP7 promoted the 786-O cells ' proliferation compared to the unprocessed group, and the difference between these two groups was, respectively, statistically significant (P =.0006, P =.0004)."
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"Silencing of KDM6B reversed the promoting effect on autophagy and proliferation induced by overexpression of USP7."
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"To explore whether abrogation of USP7 can suppress GC cell proliferation, knockout of USP7 in MGC-803 was applied."
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"The results showed that the overexpression of Usp7 in FGSCs significantly inhibited their proliferation compared with that of controls (Fig. 4d, e)."
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"Moreover, USP7 knockdown in PDAC cells also suppressed TOPFlash luciferase activity (Fig. 5f), cell proliferation activity (Fig. 5g) and invasive potential (Fig. 5h)."
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"Intervention in USP7 to induce the downregulation of Ki-67 protein could inhibit proliferation of NSCLC cells and even increase the sensitivity of the cells to some chemotherapy drugs."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"Hence, abrogation of USP7 inhibits proliferation of GC cells through promoting the stability of P53."
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"However, to the best of our knowledge, no studies have evaluated the mechanism and function of Usp7 in determining FGSC self-renewal and differentiation.In this paper, we report for the first time that Usp7 inhibited the proliferation of FGSCs and promoted their differentiation via genomic methylation."
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"The result showed that cell proliferation was inhibited by the knockdown of nucleolin, HAUSP, and nucleolin and HAUSP double-knockdown, respectively (XREF_FIG)."
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"42 It has also been shown that both up or down-regulation of USP7 protein expression reduces cell proliferation in colon cancer and tumour development in vivo, as a consequence of increasing p53 levels.43Interleukin-6 (IL-6) stimulates STAT3 activation in normal physiological conditions and is controlled via negative feedback mechanisms."
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"The results of Cell Counting Kit-8 and 5-ethynyl-20-deoxyuridine assays showed that the viability and proliferation of FGSCs were negatively regulated by Usp7."
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"Knockdown of USP7 inhibits proliferation of ovarian cancer cells."
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"The following is/are the supplementary data related to this article : 3.5 Abrogation of USP7 suppressed GC cell proliferation and cell cycle progression."
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"Precise regulation of USP7 expression and activity is therefore necessary for maintaining proper cell proliferation, and both up- and downregulation of USP7 inhibit colon cancer cell proliferation (Be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, in the absence of stress, both HAUSP up and downregulation inhibit cell proliferation in vitro and tumor growth in vivo due to constitutively elevated p53 levels."
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"Specific silencing of USP7 using siRNA or USP7 inhibitors led to phenotypical and functional changes in M2 MPhis, favoring CD8 + T cells proliferation in vitro."
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"Importantly, abrogation of USP7 not only sensitizes GC cells to T cell mediated killing by downregulating cell surface PD-L1 levels and attenuating its interaction with PD-1, but also suppresses the proliferation of GC cells by stabilizing P53 invitro and invivo."
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"USP7 expression is also enhanced by FOXO6, which inhibits proliferation of lung carcinoma [XREF_BIBR]."
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"A previous study XREF_BIBR showed that USP7 transcriptional activation by FOXO6 suppresses lung cancer progression and that USP7 inhibited cell proliferation in EC."
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"Hence, we demonstrate that abrogation of USP7 can suppress GC cells proliferation via stabilizing P53 invitro and invivo."
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"Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo, accompanied by downregulation of the NOTCH1 protein level."
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"In addition, we found that USP7 depleted cells transfected with exogenous ARMC5 fully prevented the cell proliferation using the CCK-8 assay."
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