IndraLab

Statements

PSMD14 activates UIMC1. 4 / 4
| 4
reach
"POH1 is recruited to the IRIF core in a BRCA1 dependent manner, and promotes the clearance of RAP80, the ubiquitin chain and 53BP1 from the IRIF core in G2 phase cells in the late stages of DDR [XREF_BIBR]."
26983989
reach
"(ii) POH1 promotes RAP80 clearance from the IRIF core but is not essential for the clearance of the ubiquitin chains, as a bipolar distribution of ubiquitin chains is regained following combined depletion of POH1 and RAP80."
24013561
reach
"One proposed model is that POH1 degrades RAP80 and the loss of RAP80 dependent protection of the ubiquitin chain promotes the removal of ubiquitin, leading to the removal of 53BP1 from the IRIF; however, the detailed molecular mechanism remains to be elucidated."
30831436
reach
"The detailed molecular mechanism remains to be elucidated, but one proposed model is that POH1 degrades RAP80 and the loss of RAP80 dependent protection of the ubiquitin chain promotes the removal of ubiquitin, leading to the removal of 53BP1 from the core of IRIF [XREF_BIBR]."
26983989