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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to RASSF6 activates apoptotic process. 1 / 1

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"RASSF6 interacts with MDM2, stabilizes p53, and induces apoptosis and cell-cycle arrest.17 RASSF6 forms a complex with MST1/2, but, in contrast to RASSF1A and MST2, RASSF6 and MST1/2 form a complex and inhibit each other under basal conditions.18 However, when certain stimuli, such as okadaic acid treatment, trigger dissociation of the complex, the Hippo pathway is activated and, simultaneously, RASSF6 induces apoptosis independently of the Hippo pathway."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...