IndraLab

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CREBBP inhibits CREBBP. 12 / 14
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"These results indicated that Ser 1382 and Ser 1386 phosphorylation by IKKalpha promotes the interaction of CBP with p65 and thereby decreases the interaction of CBP with p53.In an attempt to know whet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17434128
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"These results suggest that the loss of the HAT activity of CBP may cause RTS, as the first example of a defect of HAT activity in a human disease."
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"As little as 5 μM of MG132 was sufficient to inhibit the CBP degradation, and 10 μM was able to restore the CBP level back to the control level (Fig. 9E)."
26773386
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"This is consistent with the observations that the acetylation of KLF13 by PCAF is not required for PCAF to block CBP acetylation of KLF13), and that PCAFHAT is able to block CBP acetylation mediated d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results suggest that the loss of C-terminal domains of CBP is sufficient to cause RTS."
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"[XREF_BIBR XREF_BIBR XREF_BIBR] While the role of 16p13.3 deletions and their subsequent disruption of the CREBBP gene have been shown to cause RTS, its role in the development of specific abnormalities such as the cardiac defects is unclear."
26085772
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"CBP phosphorylation was stimulated by metformin both in vitro and in vivo (XREF_FIG), and metformin antagonized wild type CBP in luciferase assays (XREF_FIG)."
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"Mutation or deletion in the CBP gene severely affects HAT activity of CBP and the ability of CBP to transactivate CREB, indicating that loss of the HAT activity of CBP may cause RTS."
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"Suppression of endogenous CBP levels by siRNA duplexes targeting the coding region of the CBP gene produced a 62% depletion of CBP compared to the control duplex siScramble (XREF_FIG)."
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"On the other hand, Nsp1 of PEDV does not interfere IRF3 phosphorylation and nuclear translocation, but interrupts the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by promoting proteasomal degradation of CBP (Zhang et al., 2016)."
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"Our data suggest that the Nsp1 mediated CBP degradation inhibits the recruitment of CBP for enhanceosome assembly, leading to the block of IFN response."
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"XREF_BIBR A recent study showed that phosphorylation of CREB binding protein (CBP) by IKKalpha suppresses p53 mediated gene expression by switching the binding preference of CBP from p53 to NF-kappaB."
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