IndraLab

Statements

CYLD inhibits activity. 10 / 10
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"CYLD and OTULIN were not inhibiting NF-κB activity per se because the DUBs did not appreciably inhibit NF-κB activity induced by an engineered non-cleavable Met1-Ub4 protein targeted to inactive XIAP ( xref ; xref E and S3F)."
26997266
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"CYLD can inhibit NF-κB activity by deubiquitinating and inactivating TRAF2 and TRAF6, RIP, NEMO, and the NF-κB co-activator BCL-3 ( xref ; xref )."
18718859
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"Effect of H486R optineurin on CYLD-dependent inhibition of TNFα-induced NF-κB activity."
21408173
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"In fact, in vitro infection of IFN-γ-stimulated BMDMs demonstrated that CYLD inhibited activity of NF-κB resulting in reduced IL-6 production, ROS synthesis, and bacterial killing, which were all dependent on NF-κB ( xref )."
23825949
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"The finding that the increased NF-κB activity is not inhibited by over-expressed CYLD prompted us to investigate whether loss of optineurin affects levels of ubiquitinated RIP."
21408173
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"Here, we newly identified that CYLD inhibits NOD2-dependent antibacterial activity of macrophages by K63 deubiquitination of RIPK2."
26834734
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"In light of evidence that Hes1 appears to serve as a direct repressor of Cyld ( Cylindromatosis ) gene expression, with CYLD in turn inhibiting NF-κB pathway activity, the Akt impact on NF-κB and T-ALL may involve collaboration of Akt with other signaling components ( xref )."
22473959
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"CYLD inhibits HDAC6 activity by binding to its catalytic domains."
19893491
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"However, CYLD strongly inhibited TBK1-induced ISRE reporter activity, whereas USP21 had no obvious effect on TBK1-induced ISRE reporter activity (unpublished data)."
24493797
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"Consistent with these previous studies, CYLD strongly inhibits TBK1-induced ISRE reporter activity (unpublished data)."
24493797