IndraLab

Statements

ATM phosphorylates PAN2. 4 / 4
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"As shown in Supplementary Fig.  xref , xref , reconstitution of USP52-deficient cells with WT USP52 but not USP52 S1003A rescued USP52 depletion-induced defects, including CHK1 and RPA2 phosphorylation and IR and PARPi response, suggesting that USP52 phosphorylation by ATM is important for proper DDR."
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"Phosphorylation of USP52 by ATM under IR treatment."
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"These results suggest that USP52 phosphorylation by ATM is important for its role in regulating DNA end resection and HR through regulating CtIP deubiquitination."
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"We further evaluated whether USP52 phosphorylation by ATM affects CHK1 and RPA2 phosphorylation and render cells resistant to cancer therapy."
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