IndraLab

Statements

USP22 decreases the amount of CDKN1A. 9 / 9
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"GSK3beta- and USP22 dependent KDM1A stabilization is required for the demethylation of histone H3K4, thereby repressing BMP2, CDKN1A and GATA6 transcription, which results in cancer stem cell self-renewal and glioblastoma tumorigenesis."
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"USP22 has also been demonstrated to inhibit transcription of the p21 gene by deubiquitinating the transcriptional regulator, FBP1, leading to cell proliferation and tumorigenesis."
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"USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression."
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"Recent studies have demonstrated that USP22 can inhibit the transcription of the p21 gene by de-ubiquitinating the transcriptional regulator FBP1, leading to cell proliferation and tumorigenesis [XREF_BIBR]."
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"In MGC-803 cells and SGC-7901 cells, knockdown of USP22 and BMI1 both increased P21 expression and reduced the expression of CSC stemness genes of CD133 and SOX2."
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"USP22 also suppresses CDKN1A and p21 -locus expression by deubiquitinating its transcriptional repressor FBP1 (Atanassov and Dent, 2011), and acts as a negative regulator of the tumor suppressor p53 b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that USP22 silencing in A549 and NCI-H460 cells increased the protein expression of p53, p21 and Bax, the key p53 signal molecules (XREF_FIG A), suggesting that p53 activation plays a role in USP22 silencing induced growth inhibition."
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"Furthermore, our results showed that USP22 deletion caused down -- regulation of cyclin D2 expression and up -- regulation of p15 and p21 expression."
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"We found that USP22 depletion inhibited the proliferation of the human GC cell lines MGC-803 and SGC-7901 cells and increased expression of P21, indicating cell cycle arrest [XREF_BIBR]."
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