IndraLab

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USP22 decreases the amount of CDKN1A. 15 / 15
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"In MGC-803 cells and SGC-7901 cells, knockdown of USP22 and BMI1 both increased P21 expression and reduced the expression of CSC stemness genes of CD133 and SOX2."
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"Moreover, USP22 knockdown upregulates the transcription of p21 by upregulating the ubiquitylation of FBP1."
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"Recent studies have demonstrated that USP22 can inhibit the transcription of the p21 gene by de-ubiquitinating the transcriptional regulator FBP1, leading to cell proliferation and tumorigenesis [XREF_BIBR]."
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"Furthermore, our results showed that USP22 deletion caused down -- regulation of cyclin D2 expression and up -- regulation of p15 and p21 expression."
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"We found that USP22 depletion inhibited the proliferation of the human GC cell lines MGC-803 and SGC-7901 cells and increased expression of P21, indicating cell cycle arrest [XREF_BIBR]."
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"In pharyngeal carcinoma, knockdown of USP22 not only upregulated p21 expression but also upregulated p27 expression and suppressed retinoblastoma protein (RB) phosphorylation."
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"USP22 has also been demonstrated to inhibit transcription of the p21 gene by deubiquitinating the transcriptional regulator, FBP1, leading to cell proliferation and tumorigenesis."
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"USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression."
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"A previous study demonstrated that USP22 could inhibit the transcription of the cyclin-dependent kinase inhibitor 1A (p21) gene by deubiquitinating the transcriptional regulator fructose-1,6-bisphosphatase (FBP1) (5)."
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"Furthermore, USP22 small interfering (si)RNA decreased the expression of Cyclin B and Survivin, and increased the expression of p21 in HCC (7)."
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"USP22 siRNA also increased the expression of p21 and reduced the expression of Cyclin B in OSCC cells."
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"We found that USP22 silencing in A549 and NCI-H460 cells increased the protein expression of p53, p21 and Bax, the key p53 signal molecules (XREF_FIG A), suggesting that p53 activation plays a role in USP22 silencing induced growth inhibition."
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"USP22 also suppresses CDKN1A and p21 -locus expression by deubiquitinating its transcriptional repressor FBP1 (Atanassov and Dent, 2011), and acts as a negative regulator of the tumor suppressor p53 b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recent studies (112) have shown that USP22 represses the transcription of the p21 gene by removing ubiquitin chains that regulate Lys 63 linkages on far upstream element–binding protein 1 (FBP1), leading to cell proliferation and tumorigenesis.The role of USP22 in the tumor cell cycle cannot be ignored."
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"These results strongly suggest that HuCD26mAb-mediated targeting of CD26 suppresses proliferation of MPM cells via downmodulation of USP22 in the nucleus.Based on our experimental findings, Fig. 3 G d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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