IndraLab

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KCNQ4 activates potassium(1+). 7 / 7
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"Similarly, the two KCNQ4 pore-region variants identified in our study produced no detectable potassium currents and were completely nonrescuable by the application of PIP5K, channel openers, or both."
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"Therefore, retigabine and ZnPy may not only complement each other but also exert synergistic effects when combined with outstripped WT channel activity in terms of potentiating defective KCNQ4-mediated potassium currents."
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"OHC survival critically depends on a specific K+ conductance (I (K, n)) mediated by KCNQ4 (Kv7.4) channels."
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"Kcne1, Kcnq1, and Kcnq4 encode subunits of inward rectifier voltage activated potassium channels."
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"In accordance, stronger potentiation of KCNQ4-mediated potassium currents in OHCs was previously demonstrated when retigabine was combined with ZnPy ."
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"The combined application of channel openers (Ret/ZnPy) potentiated the KCNQ4-mediated potassium currents of the WT protein by more than twofold (Fig. 2c, d)."
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"The resulting KCNQ4-mediated potassium currents appeared to inversely correlate with the concentration of mutant cDNA (Fig. S2), without definite dominant-negative effects of the mutant proteins on the WT protein (peak current density of KCNQ4WT:vector (2:2): 131.7 ± 21.1 pA/pF at +40 mV, n = 11; peak current density of KCNQ4WT:KCNQ4p.A271_D272del (2:2): 69.8 ± 19.9 pA/pF at +40 mV, n = 7; peak current density of KCNQ4WT:KCNQ4p.G319D (2:2): 152.7 ± 45.7 pA/pF at +40 mV, n = 11; peak current density of KCNQ4WT:KCNQ4p.R331Q (2:2): 55.1 ± 17.8 pA/pF at +40 mV, n = 6)."
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