IndraLab

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"Fig. 3 shows that USP22 promoted cell proliferation via the c-Myc/cyclin D2 pathway, BMI-1 pathway and p53, as evident by the results of knocking down USP22 in HeLa cells."
26143114
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"Studies have shown that overexpression of USP22 can enhance the inhibitory effect of cell cycle inhibitors such as p21 and enhance the proliferation of tumor cells, thus promoting the occurrence and development of tumors [XREF_BIBR]."
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"18 In lung cancer, USP22 promotes cell survival and proliferation by upregulating the expression levels of stemness-related markers."
36528490
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"XREF_BIBR - XREF_BIBR Zhang and colleagues have demonstrated that ectopic overexpression of USP22 promotes cell proliferation and that suppression of USP22 expression by small hairpin RNA induces cell cycle arrest in human lung cancer cells."
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"Our results indicate that USP22 promotes cell proliferation, migration, invasion, and cell cycle transition, while inhibiting apoptosis in gastric cancer cells."
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"Accordingly, we observed similar patterns in the colony forming efficiency of LvUSP22 transfected PC9 cells and USP22-shRNA transfected H1975 cells, suggesting that USP22 positively regulates cell pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
32063746
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"USP22 promotes cell proliferation, migration, and invasion in multiple cancers, including glioma, lung adenocarcinoma, thyroid carcinoma, colorectal cancer, and gastric cancer [27–31]."
32063746
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"USP22 is also upregulated in many cancer cells and activates the proliferation, migration, and invasion of gastric cancer, colorectal cancer, and breast cancer XREF_BIBR - XREF_BIBR."
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"Previous studies have demonstrated that the USP22 gene promotes the proliferation of esophageal carcinoma and lung breast, colorectal and bladder cancer cells."
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"Collectively, our findings indicate that miR-200b-5p-mediated inhibition of USP22 attenuates cell proliferation by targeting the NF-κB signaling pathway in GC, suggesting that miR-200b-5p and USP22 could serve as potential diagnostic or therapeutic targets for gastric cancer and other related human diseases."
39711149
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"Previous studies showed that USP22 enhances cancer cell proliferation through interaction with Rb and p53."
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"Interestingly, it was demonstrated that silencing USP22 inhibited proliferation in bladder cancer cells (Lv et al., 2011) leading to cell cycle arrest, inhibition of autophagy and decreased tumor progression representing a potential target for cancer therapy."
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"Furthermore, USP22 promotes the proliferation, migration, and invasion of pancreatic, breast, gastric, and colorectal cancers and is associated with poor prognosis [56-59]."
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"For instance, USP22 enhanced cell proliferation via increasing surviving stability in renal cell carcinoma (RCC) cells (37)."
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"Since Sirt1 is a suppressor for p53 functions, it is possible that USP22 promotes cell proliferation and suppresses apoptosis through regulation of Sirt1 to antagonize p53 function."
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"These findings indicate that USP22 may promote gastric cancer cell proliferation by accelerating the G2/M progression."
32063746
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"We found that SOS1 silencing effectively reversed USP22-induced changes in cell proliferation, migration, invasion, and apoptosis in vitro."
32063746
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"In bladder cancer, silencing USP22 by siRNAs induced cell cycle arrest and attenuated cell proliferation (50)."
37215134
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"Previous studies have reported that USP22 silencing inhibits the proliferation of various tumor cells."
23599781
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"USP22 overexpression is accompanied by an increase in FoxM1 expression and USP22 increases FoxM1 expression to promote G1/S transition and cell proliferation through promoting beta-catenin nuclear translocation in PDA cell lines."
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"Moreover , there was no synergistic effect on cell proliferation when both USP22 and YAP were depleted ( Fig. 4D ; P > 0.05 ) , suggesting that USP22 promoted cell proliferation largely through YAP ."
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"Inhibition of USP22 by miR-200b-5p represses gastric cancer cell proliferation and migration by targeting the NF-κB signaling pathway."
39711149
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"We drew a conclusion that USP22 could increase the abilities of proliferation, migration and invasion of glioma cells, and promote the growth and development of glioma."
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"This novel finding suggests that USP22 promotes cell proliferation via the c-Myc and cyclin D2 pathway, leading to cancer development."
24466336
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"USP22 knockdown significantly decreased in vitro survival, proliferation, migration, and invasiveness of GC cells compared with the controls."
31689236
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"USP22 silencing inhibits the tumor cell proliferation [76]."
34419060
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"Through measuring the proliferation, migration and invasion of SW480 and SW620 cells, we uncovered that USP22 knockdown could suppress the proliferation, migration and invasion of CRC cells, while USP22 overexpression had an opposite effect (Supplement Figure 2)."
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"Nevertheless, significant evidence is accumulating that indicates USP22 expression promotes cell cycle progression in certain cancer cell lines and that USP22 overexpression may enhance proliferation of cancer cells by facilitating premature transition through various cell cycle stages."
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"Ubiquitin specific protease 22 (USP22) cooperates with TGF-β to promote cell proliferation in OC (93)."
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"USP22 was highly expressed in NPC cells and promoted cell viability and proliferation."
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"Together, these results support that USP22 promotes CRC cell proliferation and tumorigenesis by stabilizing FASN."
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"We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-beta1 (TGFB1)."
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"USP22 silencing inhibits GC cells proliferation."
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"Notably, USP22 knockout dramatically suppressed in vitro proliferation, colony formation; and angiogenesis, growth, metastasis of A549 and H1299 in mouse xenograft model, and significantly prolonged survival of metastatic cancer bearing mice."
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"A previous study showed that USP22 is required for cell cycle progression, and USP22 deletion suppresses proliferation of multiple cancer cells [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
28415621
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"USP22 knockdown inhibits GC cell proliferation in vitro."
31689236
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"Moreover, EdU assay results showed that USP22 knockdown significantly reduced proliferation of BGC-823 and HGC-27 cells compared with the controls (Figure 2D)."
31689236
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"Co-expression of USP22 and BMI1 can accelerate tumor proliferation, stemness, and drug resistance (35)."
35935969
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"For example, USP22 stimulates cellular proliferation via many pathways, including transcriptional activation of Myc-target genes (Zhang et al., 2008b; Zhao et al., 2008), inhibition of p53 tumor suppr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
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"Mechanistically USP22 has been shown to promote cell proliferation through different mechanisms in a variety of model systems."
24647359
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"USP22 promotes the proliferation of NPC."
27051294
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"In cell cultures, USP22 overexpression increased CCA cell proliferation and mobility, and induced epithelial-to-mesenchymal transition (EMT)."
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"In previous studies, silencing of USP22 significantly inhibited tumor cell proliferation."
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"P-p38 MAPK inhibited the expression of USP22, and overexpression of USP22 eliminated the inhibitory roles of P-p38 MAPK on tumor growth, as well as cell proliferation, migration and invasion."
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"This work indicates that USP22 promotes cell proliferation via the c-Myc/cyclin D2 pathway, BMI-1 pathway and p53."
26143114
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"This result suggests that USP22 is a potential diagnostic and a prognostic marker for GC patients.Previous studies show that USP22 promotes proliferation and survival of anaplastic thyroid [6], hepatic [13], colorectal [28], and bladder [29] cancer cells."
31689236
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"For example, USP2, USP22, USP28, and USP37 stabilize c-Myc expression and, thus, stimulate the proliferation of many tumour cells [58–61] ."
34678225
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"USP22 knockdown decreases in vitro proliferation, migration and invasiveness of GC cells."
31689236
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"These results demonstrate that USP22 promotes cell proliferation and plays an oncogenic role in NPC cells."
27051294
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"This novel finding suggests that USP22 promotes cell proliferation via the c-Myc/cyclin D2 pathway and BMI-1 pathway."
26143114
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"For instance, USP22, a ubiquitin hydrolase, enhances the proliferation, angiogenesis, and recurrence of NSCLC."
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"USP22 can also enhance the telomerase reverse transcriptase (TERT)/p53 signaling pathway [ 65 ] and promote cell proliferation and DNA repair (see Fig. 1 )."
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"USP22 is regarded as an important driver of the cell cycle and telomere maintenance in cancer cells, allowing unregulated proliferation of tumor cells with a large number of DNA replication errors."
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"Overexpression of USP22 restored the inhibitory effect of miR-132-3p on CRC cell proliferation and metastasis."
35935969
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"Furthermore, overexpression of USP22 stimulates breast cancer cell proliferation and aggregation and increases c-MYC tumorigenic activity (65)."
35935969
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
31689236
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"In addition, USP22 can regulate protein function and promote cell proliferation via deubiquitination; therefore, the downregulation of this gene can cause G0/G1 phase cell cycle arrest, thereby inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo."
25547493
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"Knockdown of USP22 significantly inhibited the viability of CAL-62 and 8505C cells, and impaired proliferation as revealed by reduced EdU incorporation in CAL-62 and 8505C cells."
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"In PDAC, USP22 accelerates cancer cell proliferation by targeting DYRK1A (88)."
35935969
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"USP22 silencing by shRNA inhibits proliferation, induces apoptosis and arrests cells at the G0/G1 phases in NSCLC cells and curbs human NSCLC tumor growth in a mouse xenograft model."
25547493
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"USP22 has also been shown to promote cell proliferation through activating oncogenic proteins, such as BMI-1, c-MYC and Sirt1 [XREF_BIBR, XREF_BIBR, XREF_BIBR], and antagonizing tumor suppressors, such as p53 [XREF_BIBR, XREF_BIBR]."
25547493
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"USP22 silencing inhibits the proliferation, invasion, and EMT of OS cells in vitro ."
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"By contrast, USP22 was overexpressed in NPC cells and promoted the proliferation of NPC."
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"iv ) The downregulation of USP22 not only suppresses multidrug resistance-associated protein 1 ( MRP1 ) , enhances the intracellular accumulation of sorafenib , and finally inhibits cell proliferation and cancer angiogenesis , but also inhibits glycolysis in hepatocellular carcinoma ( HCC ) cells , enhancing sorafenib chemosensitivity and impairing cell metabolism ."
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"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
25547493
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"Consistently, overexpression of either E2F6 or USP22 enhanced the proliferation of liver cancer cells (Supplementary."
34339800
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"Of note, DUSP1 expression was sufficient to abrogate the enhancement in cell proliferation caused by USP22 overexpression ( Fig. 6 C and D)."
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"Together, these data showed that USP22 silencing inhibited the proliferation of ATC cells in vitro."
27145278
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"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
32294625
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"Moreover, there was no synergistic effect on cell proliferation when both USP22 and YAP were depleted (XREF_FIG; P> 0.05), suggesting that USP22 promoted cell proliferation largely through YAP."
33777217
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"The mechanistic details regarding how USP22 promotes proliferation and survival in GC cells requires further in depth study."
31689236
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"USP22 has been shown to promote the proliferation of human non small cell lung cancer cell H1129 and human bladder cancer cell EJ by facilitating cell cycle progression, which was supported by the observed G1 phase arrest and concomitant reduction in the S and G2/M phase when USP22 was depleted [XREF_BIBR, XREF_BIBR]."
27145278
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"Consistently, we demonstrated that USP22 silencing inhibited the proliferation of human ATC cells (8505C and CAL-62)."
27145278
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"A delayed G1-to-S transition is usually accompanied by a reduction in the phosphorylation of Rb, which is indeed observed in USP22 knockdown ATC cells in our study, suggesting that USP22 may promote cell proliferation by modulating the Rb/E2F pathway [XREF_BIBR]."
27145278
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"USP22 knockdown inhibits cell proliferation and induces cell cycle arrest in IEC-6 cells after hypoxia/reoxygenation injury."
30809082
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"USP22 overexpression promotes cell proliferation in IEC-6 cells after hypoxia/reoxygenation injury."
30809082
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"Thus, our results demonstrated that USP22 overexpression may promote cell proliferation and viability in this process."
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"Third, and most critically, USP22 robustly promoted cell growth and proliferation in the absence of androgen."
24197134
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"USP22 can also suppress apoptosis and promote cell proliferation by antagonizing p53 function through the regulation of SIRT1[29,30]."
30809082
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"As shown in XREF_FIG, control cells significantly reduced BrdU incorporation upon hormone deprivation (compare XREF_FIG), whereas, USP22 upregulation induced a 2.7-fold increase in BrdU incorporation and substantially enhanced cell proliferation rates in the absence of androgen."
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"Our data indicate that USP22 promotes cell proliferation in HCC cells and the effect of USP22 on cell growth is partially related to VEGFA.We observed that USP22 knockdown resulted in morphological atrophy of HCC cells and enhanced cell-to-cell adhesion to be difficult to form association between cell colonies (Fig. 5D)."
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"For instance, Ding et al. demonstrated that USP22 silencing inhibited in vitro proliferation and in vivo tumor growth of non small cell lung cancer cells XREF_BIBR."
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"Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells."
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"Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance related proteins (MDR1, LRP, MRP1)."
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"Therefore, USP22 promoted both cell proliferation and cell metastasis in colon cancer cells and upregulation of USP22 predicted poor prognosis for patients with colon cancer.USP22 belongs to the deubiquitinase family of proteins and strictly regulates gene expression through histone deubiquitination or acetylation procession (12,13,15,16)."
31612065
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"However, Ao et al (31) reported that USP22 promoted cell proliferation but inhibited cell invasion in SW480 colon cancer through the STAT3/MMP9 pathway (31)."
31612065
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"In these experiments, USP22 increased the proliferation in HCT116 and SW480 colon cancer cell lines, whereas the metastasis promoting effects on colon cancer cells were cell specific."
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"USP22 alterations are associated with pro-proliferative oncogenes , including AR and MYC [ 8] , and accordingly , data demonstrated that suppression of USP22 expression decreased cell proliferation in PCa models ( Figure 2D ) ."
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"Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer."
31612065
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"Knockdown of USP22 reduces proliferation in human colon cancer cells."
31612065
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"Therefore, knockdown of USP22 significantly reduced cell proliferation in human colon cancer cells."
31612065
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"Therefore, Bmi-1 and Cyclin D2 may be involved in the promotion of proliferation and metastasis of colon cancer cells by USP22."
31612065
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"Interestingly, our data showed that USP22 promotes the proliferation but inhibits the differentiation of NSCs in the dentate gyrus (DG)of the hippocampus soon after TBI."
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"Furthermore, USP22 promotes the proliferation and regeneration of damaged intestinal tissues in the context of II/R [29]."
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"Lentivirus mediated knockdown of USP22 repressed the rate of proliferation and capacity of colony formation of BxPC3 and CAPAN1 cancer cells and USP22 overexpression promoted the proliferation and capacity of the colony formation of BxPC3 and CAPAN1 cancer cells."
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"These results demonstrate that inhibition of USP22 expression can suppress Sao-2 cell proliferation."
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"USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin."
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"Silencing USP22 by interfering with RNA inhibits proliferation and induces cell cycle arrest in BCa cells (133)."
37497216
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"Silencing USP22 in Bel/Fu cells inhibited proliferation, migration, invasion and chemoresistance both in vitro and in vivo."
28445968
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"Our data further indicates that USP22 promotes the proliferation of hepatocellular carcinoma cells via deubiquitinating and stabilizing cyclin-dependent kinase 11B (CDK11B)."
40341781
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"In the Huh‐7 and Hep‐3B cell lines, knockdown of USP22 slowed cell proliferation, while overexpression accelerated it (Figure 3A)."
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"We found that USP22 knockdown could inhibit the glycolytic pathway in osteosarcoma cells, suppress cell proliferation, migration and invasion, and promote cancer cell apoptosis.Glycolysis is one of the major pathways for cells to generate energy by converting glucose into lactate and producing ATP (Lunt & Vander Heiden, 2011)."
38784391
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"We showed that USP22 knockdown inhibited cell proliferation, induced cell cycle arrest and apoptosis ( Fig. 6 C–E) in the same way as that achieved by ectopic miR-30e-5p expression."
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"The two USP22 knockdown cell lines grew significantly (P < 0.05) more slowly than did the the two control cell lines, suggesting that USP22 positively regulated cell proliferation."
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"MiR-30e-5p binds to the 3ʹUTR of USP22 and negatively regulates USP22-mediated cell proliferation, cell cycle arrest, and apoptosis to slow down NSCLC progression."
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"19 However, there has been a lack of thorough investigation into the role of USP22 in hepatocellular carcinoma development and Sorafenib resistance.In this study, we demonstrate that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising cyclin‐dependent kinase 11B (CDK11B)."
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"2.1 USP22 promotes the proliferation of hepatocellular carcinoma cells."
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"27 One study showed that knockdown of USP22 decreased cell proliferation in several cancer cell lines, suggesting that USP22 might be a novel therapeutic target in cancer."
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"Similarly, USP22 knockdown decreases cell proliferation in several cancer cell lines [53,58,59] ."
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"To further validate that USP22 increases hepatocellular carcinoma cell proliferation by stabilising CDK11B protein, we overexpressed His‐CDK11B in USP22 knockout cells (Figure 4F) and evaluated cell proliferation."
40341781
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"We have demonstrated that USP22 depletion inhibits hepatocellular carcinoma cell proliferation and promotes the sensitivity of hepatocellular carcinoma cells to Sorafenib‐induced ferroptosis by in vitro assays."
40341781
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"USP22 maintained GC cell stemness by stabilizing BMI1 and promoted proliferation and metastasis by activating the FOXO1 and YAP signaling pathway [47,50]."
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"Altogether, these results provided evidence that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising CKD11B and increases Sorafenib resistance through reducing H2BK120ub level and TFRC transcription in vivo.3 DISCUSSION."
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"We showed that USP22 protein expression is detected in clinical specimens of MPM and that USP22 knockdown, as well as CD26 knockdown, significantly inhibits the growth and proliferation of MPM cells i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Silencing of USP22 downregulates COX-2 and thus inhibits cancer cell proliferation in OSCC by direct interaction leading to modulation of stability and activity of COX-2 through controlling of its ubiquitination status."
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"USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising CDK11B and enhances resistance to Sorafenib by inhibiting ferroptosis through the USP22/H2BK120ub/TFRC axis.So far, more than 40 USPs have been directly or indirectly associated with relevant cancer processes."
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"Compared with the corresponding negative control, USP22 overexpression significantly promoted cell proliferation, migration, and invasion in SGC7901 cells, whereas USP22 knockdown significantly inhibited these behaviors in AGS cells (Fig. 2b–d)."
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"As shown in Fig. 1 C, knockdown of USP22 by shRNA (USP22-shRNA-1 or -2) significantly inhibited in vitro proliferation of MESO1 (left panel) and JMN (right panel)."
30197002
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"In addition, the expression of USP22 promotes the proliferation of osteosarcoma cells in a glycolytic dependent manner both in vitro and in vivo, while the knockout of USP22 is the opposite."
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"USP22 promotes cell proliferation, migration, and invasion in gastric cancer cells."
32063746
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"These findings suggest that USP22 accelerates gastric cancer cell proliferation, possibly by suppressing cell apoptosis and promoting the G2/M transition."
32063746
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"Subsequent experiments showed that USP22 knockdown resulting from up-regulation of miR-30e-5p could inhibit proliferation, invasion, migration, and EMT in 5-8F cells."
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