IndraLab

Statements

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"USP22 silencing inhibits the tumor cell proliferation [76]."
34419060
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"By contrast, USP22 was overexpressed in NPC cells and promoted the proliferation of NPC."
27051294
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"We found that SOS1 silencing effectively reversed USP22-induced changes in cell proliferation, migration, invasion, and apoptosis in vitro."
32063746
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"Silencing of USP22 downregulated COX-2, decreased its half-life, and inhibited lung carcinoma cell proliferation by directly interacting with and modulating the stability and activity of COX-2 through the regulation of its ubiquitination status."
25817787
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"Previous studies showed that USP22 enhances cancer cell proliferation through interaction with Rb and p53."
29200868
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"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
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"USP22 has been shown to promote the proliferation of human non small cell lung cancer cell H1129 and human bladder cancer cell EJ by facilitating cell cycle progression, which was supported by the observed G1 phase arrest and concomitant reduction in the S and G2/M phase when USP22 was depleted [XREF_BIBR, XREF_BIBR]."
27145278
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"Moreover, there was no synergistic effect on cell proliferation when both USP22 and YAP were depleted (XREF_FIG; P> 0.05), suggesting that USP22 promoted cell proliferation largely through YAP."
33777217
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"USP22 silencing by shRNA inhibits proliferation, induces apoptosis and arrests cells at the G0/G1 phases in NSCLC cells and curbs human NSCLC tumor growth in a mouse xenograft model."
25547493
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"Moreover, EdU assay results showed that USP22 knockdown significantly reduced proliferation of BGC-823 and HGC-27 cells compared with the controls (Figure 2D)."
31689236
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"USP22 knockdown significantly decreased in vitro survival, proliferation, migration, and invasiveness of GC cells compared with the controls."
31689236
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
32063746
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"Interestingly, it was demonstrated that silencing USP22 inhibited proliferation in bladder cancer cells (Lv et al., 2011) leading to cell cycle arrest, inhibition of autophagy and decreased tumor progression representing a potential target for cancer therapy."
30524288
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"USP22 alterations are associated with pro-proliferative oncogenes , including AR and MYC [ 8] , and accordingly , data demonstrated that suppression of USP22 expression decreased cell proliferation in PCa models ( Figure 2D ) ."
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"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo."
25547493
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"USP22 promotes cell proliferation, migration, and invasion in multiple cancers, including glioma, lung adenocarcinoma, thyroid carcinoma, colorectal cancer, and gastric cancer [27–31]."
32063746
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"Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells."
20824490
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"For example, USP22 stimulates cellular proliferation via many pathways, including transcriptional activation of Myc-target genes (Zhang et al., 2008b; Zhao et al., 2008), inhibition of p53 tumor suppr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
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"Silencing USP22 in Bel/Fu cells inhibited proliferation, migration, invasion and chemoresistance both in vitro and in vivo."
28445968
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"Interestingly, our data showed that USP22 promotes the proliferation but inhibits the differentiation of NSCs in the dentate gyrus (DG)of the hippocampus soon after TBI."
35700816
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"A previous study showed that USP22 is required for cell cycle progression, and USP22 deletion suppresses proliferation of multiple cancer cells [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
28415621
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"USP22 was highly expressed in NPC cells and promoted cell viability and proliferation."
27051294
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"27 One study showed that knockdown of USP22 decreased cell proliferation in several cancer cell lines, suggesting that USP22 might be a novel therapeutic target in cancer."
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"Together, these results support that USP22 promotes CRC cell proliferation and tumorigenesis by stabilizing FASN."
36333288
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"USP22 is also upregulated in many cancer cells and activates the proliferation, migration, and invasion of gastric cancer, colorectal cancer, and breast cancer XREF_BIBR - XREF_BIBR."
33664230
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"Through measuring the proliferation, migration and invasion of SW480 and SW620 cells, we uncovered that USP22 knockdown could suppress the proliferation, migration and invasion of CRC cells, while USP22 overexpression had an opposite effect (Supplement Figure 2)."
32547062
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"USP22 has also been shown to promote cell proliferation through activating oncogenic proteins, such as BMI-1, c-MYC and Sirt1 [XREF_BIBR, XREF_BIBR, XREF_BIBR], and antagonizing tumor suppressors, such as p53 [XREF_BIBR, XREF_BIBR]."
25547493
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"USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin."
32973959
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"USP22 overexpression is accompanied by an increase in FoxM1 expression and USP22 increases FoxM1 expression to promote G1/S transition and cell proliferation through promoting beta-catenin nuclear translocation in PDA cell lines."
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"A delayed G1-to-S transition is usually accompanied by a reduction in the phosphorylation of Rb, which is indeed observed in USP22 knockdown ATC cells in our study, suggesting that USP22 may promote cell proliferation by modulating the Rb/E2F pathway [XREF_BIBR]."
27145278
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"In previous studies, silencing of USP22 significantly inhibited tumor cell proliferation."
25241842
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"The mechanistic details regarding how USP22 promotes proliferation and survival in GC cells requires further in depth study."
31689236
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"Knockdown of USP22 significantly inhibited the viability of CAL-62 and 8505C cells, and impaired proliferation as revealed by reduced EdU incorporation in CAL-62 and 8505C cells."
27145278
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"Together, these data showed that USP22 silencing inhibited the proliferation of ATC cells in vitro."
27145278
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"XREF_BIBR - XREF_BIBR Zhang and colleagues have demonstrated that ectopic overexpression of USP22 promotes cell proliferation and that suppression of USP22 expression by small hairpin RNA induces cell cycle arrest in human lung cancer cells."
23361242
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"iv ) The downregulation of USP22 not only suppresses multidrug resistance-associated protein 1 ( MRP1 ) , enhances the intracellular accumulation of sorafenib , and finally inhibits cell proliferation and cancer angiogenesis , but also inhibits glycolysis in hepatocellular carcinoma ( HCC ) cells , enhancing sorafenib chemosensitivity and impairing cell metabolism ."
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"Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance related proteins (MDR1, LRP, MRP1)."
28445968
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"Lentivirus mediated knockdown of USP22 repressed the rate of proliferation and capacity of colony formation of BxPC3 and CAPAN1 cancer cells and USP22 overexpression promoted the proliferation and capacity of the colony formation of BxPC3 and CAPAN1 cancer cells."
32687947
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"Compared with the corresponding negative control, USP22 overexpression significantly promoted cell proliferation, migration, and invasion in SGC7901 cells, whereas USP22 knockdown significantly inhibited these behaviors in AGS cells (Fig. 2b–d)."
32063746
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"This novel finding suggests that USP22 promotes cell proliferation via the c-Myc and cyclin D2 pathway, leading to cancer development."
24466336
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"Previous studies have demonstrated that the USP22 gene promotes the proliferation of esophageal carcinoma and lung breast, colorectal and bladder cancer cells."
23599781
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"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
25547493
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"These findings suggest that USP22 accelerates gastric cancer cell proliferation, possibly by suppressing cell apoptosis and promoting the G2/M transition."
32063746
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"Subsequent experiments showed that USP22 knockdown resulting from up-regulation of miR-30e-5p could inhibit proliferation, invasion, migration, and EMT in 5-8F cells."
30338802
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"USP22 promotes the proliferation of NPC."
27051294
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"Notably, USP22 knockout dramatically suppressed in vitro proliferation, colony formation; and angiogenesis, growth, metastasis of A549 and H1299 in mouse xenograft model, and significantly prolonged survival of metastatic cancer bearing mice."
31842906
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"Silencing USP22 reduced the stemness and proliferation of GSCs, and increased its apoptosis in response to hypoxia."
32070708
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"As shown in XREF_FIG, control cells significantly reduced BrdU incorporation upon hormone deprivation (compare XREF_FIG), whereas, USP22 upregulation induced a 2.7-fold increase in BrdU incorporation and substantially enhanced cell proliferation rates in the absence of androgen."
24197134
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"Third, and most critically, USP22 robustly promoted cell growth and proliferation in the absence of androgen."
24197134
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"USP22 promotes cell proliferation, migration, and invasion in gastric cancer cells."
32063746
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"P-p38 MAPK inhibited the expression of USP22, and overexpression of USP22 eliminated the inhibitory roles of P-p38 MAPK on tumor growth, as well as cell proliferation, migration and invasion."
35356205
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"We showed that USP22 protein expression is detected in clinical specimens of MPM and that USP22 knockdown, as well as CD26 knockdown, significantly inhibits the growth and proliferation of MPM cells invitro and invivo."
30197002
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"In cell cultures, USP22 overexpression increased CCA cell proliferation and mobility, and induced epithelial-to-mesenchymal transition (EMT)."
34226501
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"Accordingly, we observed similar patterns in the colony forming efficiency of LvUSP22 transfected PC9 cells and USP22-shRNA transfected H1975 cells, suggesting that USP22 positively regulates cell pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29981430
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"We drew a conclusion that USP22 could increase the abilities of proliferation, migration and invasion of glioma cells, and promote the growth and development of glioma."
30223389
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"Consistently, we demonstrated that USP22 silencing inhibited the proliferation of human ATC cells (8505C and CAL-62)."
27145278
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"USP22 knockdown inhibits GC cell proliferation in vitro."
31689236
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"USP22 knockdown decreases in vitro proliferation, migration and invasiveness of GC cells."
31689236
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"Here, we showed that USP22 promotes cell proliferation, migration and invasion, and contributes to resistance to EGFR-TKIs in EGFR mutant lung ADC cells."
29981430
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"Mechanistically USP22 has been shown to promote cell proliferation through different mechanisms in a variety of model systems."
24647359
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"These findings indicate that USP22 may promote gastric cancer cell proliferation by accelerating the G2/M progression."
32063746
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"Nevertheless, significant evidence is accumulating that indicates USP22 expression promotes cell cycle progression in certain cancer cell lines and that USP22 overexpression may enhance proliferation of cancer cells by facilitating premature transition through various cell cycle stages."
29210986
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"These results demonstrate that USP22 promotes cell proliferation and plays an oncogenic role in NPC cells."
27051294
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"Previous studies have reported that USP22 silencing inhibits the proliferation of various tumor cells."
23599781
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"We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-beta1 (TGFB1)."
25369910
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"Moreover , there was no synergistic effect on cell proliferation when both USP22 and YAP were depleted ( Fig. 4D ; P > 0.05 ) , suggesting that USP22 promoted cell proliferation largely through YAP ."
33777217
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"Our results indicate that USP22 promotes cell proliferation, migration, invasion, and cell cycle transition, while inhibiting apoptosis in gastric cancer cells."
32063746
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"For instance, Ding et al. demonstrated that USP22 silencing inhibited in vitro proliferation and in vivo tumor growth of non small cell lung cancer cells XREF_BIBR."
27983930
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"USP22 silencing inhibits GC cells proliferation."
28415621
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"The two USP22 knockdown cell lines grew significantly (P < 0.05) more slowly than did the the two control cell lines, suggesting that USP22 positively regulated cell proliferation."
22880026
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
31689236
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"This result suggests that USP22 is a potential diagnostic and a prognostic marker for GC patients.Previous studies show that USP22 promotes proliferation and survival of anaplastic thyroid [6], hepatic [13], colorectal [28], and bladder [29] cancer cells."
31689236
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"Studies have shown that overexpression of USP22 can enhance the inhibitory effect of cell cycle inhibitors such as p21 and enhance the proliferation of tumor cells, thus promoting the occurrence and development of tumors [XREF_BIBR]."
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