IndraLab

Statements

RvD2 inhibits NLRP3. 10 / 10
| 10
reach
"In addition, the results from the present study demonstrate that RvD2 could promote the degradation of NLRP3 inflammasome and may induce the inhibition of NLRP3 inflammasome activation.LPS intraperitoneal injection was previously reported to stimulate inflammasome activation in peritoneal macrophages (1)."
34603519
reach
"These findings suggested that RvD2 may promote NLRP3 degradation through autophagy.The present study used LC-3 as the marker of autophagy and performed experiments using inhibitors to demonstrate its crucial role in NLRP3 degradation."
34603519
reach
"The in vitro experiments suggested that RvD2 promoted the NLRP3 degradation through autophagy."
34603519
reach
"Mechanistically, RvD2 was found to promote the degradation of NLRP3 through autophagy, and the inhibition of autophagy could reverse the RvD2-mediated suppression of NLRP3 inflammasome in vitro and partially reverse the inflammasome-mediated peritonitis in vivo."
34603519
reach
"The present study investigated therefore how RvD2 could inhibit NLRP3 activation."
34603519
reach
"These findings suggested that RvD2 could inhibit NLRP3 activation by promoting NLRP3 degradation via autophagy."
34603519
reach
"RvD2 promotes NLRP3 degradation through autophagy."
34603519
reach
"In vivo, in a self resolving zymosan A induced peritonitis model, RvD2 blocked the NLRP3 inflammasome leading to reduced release of IL-1beta into the exudates, repression of osteopontin, and MCP-1 expression and induction of M2 markers of resolution (i.e., CD206 and arginase-1) in peritoneal macrophages."
29601102
reach
"In addition, RvD2 may promote NLRP3 degradation through autophagy."
34603519
reach
"Furthermore, although RvD2 inhibited the activation of NLRP3 and NALP3 inflammasome (Fig. 2C), RvD2 showed the most significant suppression in NLRP3 inflammasome activation in a dose-dependent manner (Fig. 2D)."
34603519