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USP11 binds PTEN. 3 / 3
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"co-immunoprecipitation assays were performed to assess the influence of lnc-DILC overexpression or knockdown in the interaction of PTEN and USP11, and the results demonstrated a promotive effect of lnc-DILC on PTEN-USP11 association (Fig. 6d, e)."
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"Notably, wild-type (WT) USP11 deubiquitinated PTEN in vivo and in vitro, whereas the catalytically inactive USP11 C318S (CS) mutant, which could still bind to PTEN, exerted a dramatically diminished ability to deubiquitinate PTEN, and even exhibited a more heavy ubiquitinating effect (Fig.  xref and Supplementary Fig.  xref )."
30733438
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"Taken together, these results suggest that PTEN-PI3K/AKT-FOXO and USP11-PTEN integrate into a PTEN feedforward signaling network (Fig.  xref )."
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