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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 activates BACH1. 1 / 1

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reach

"Chromatin IP (ChIP)-quantitative polymerase chain reaction (qPCR) assays confirmed that Bach1 occupied the Usp7 promoter (XREF_FIG), indicating that Usp7 is a direct target of Bach1, and when Usp7 activity was down-regulated via transfection with small interfering RNAs (siRNAs) and/or treatment with the Usp7 inhibitor P5091, Nanog ubiquitination increased, pluripotency protein levels declined in WT hESCs, and the increase in pluripotency protein levels associated with Bach1 overexpression was abolished (XREF_FIG and fig."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...