IndraLab
Statements
HCN1 inhibits 3',5'-cyclic AMP. 2 / 2
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2
reach
"For example, HCN1 subunits form channels with fast voltage dependent gating and reduced cAMP sensitivity, whereas HCN2 and HCN4 channels respond more efficiently to cAMP and have slower kinetics (Santoro et al. 1998; Seifert et al. 1999; Ishii et al. 1999; Ludwig et al. 1999; this work)."
reach
"2) Developmental dysregulation of cortical and/or thalamic HCN channel expression may contribute to epileptogenesis in genetic models of absence epilepsy : In two models, the Wistar Albino Glaxo and Rijswijk (WAG and Rij) and the Genetic Absence Epileptic Rats of Strasbourg (GAERS), the relative contribution of HCN1 channels to the channel pool and thalamic I h was increased in thalamocortical relay (TC) neurons, resulting in reduced cAMP responsiveness of I h."