IndraLab

Statements

USP8 activates gefitinib. 3 / 3
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"Interestingly, the inhibition of USP8 suppresses growth of gefitinib resistant non small cell lung cancer cells, though no link to the potential impact on HIF-1alpha is reported."
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"Silencing or pharmacological inhibition of USP8 deubiquitinase, relevant in particular to the stability of RTKs such as EGFR and MET, was shown to induce death of gefitinib resistant NSCLC cells in vitro and in vivo [XREF_BIBR]."
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"In addition, studies have shown that USP8 knockdown or inhibitors can significantly reduce the viability of gefitinib-resistant and -sensitive NSCLC cells by reducing the expression of receptor tyrosine kinase (RTK).14,15Baykara et al find that the serum USP8 level in NSCLC patients was higher than in healthy individuals."
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