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"Neutralization of endogenous IL-6 by i.p. administration of the monoclonal MP5-20F3 antibody 1 h before i.v. Lm infection completely abolished the protective effect of Cyld-deficiency and all alpha-IL-6-treated Cyld -/- mice succumbed up to day 5 p.i. (XREF_FIG)."

"During chronic cellular proliferation, miR-21 supports NF-κB signals and promotes inflammation. xref miR-21 expression is controlled by the IL-6-STAT3 pathway during epithelial cell proliferation xref —a pathway essential for expansion and suppressive activity of MDSCs. xref , xref Induction of miR-21 together with miR-181b by the inflammatory cytokine IL-6 inhibits tumor suppressor proteins PTEN and CYLD, increases Akt activity and activates NF-κB, which is required for cellular proliferation and maintaining the transformed state in human epithelial cell lines. xref In this work, it was concluded that miR-21 is part of a positive feedback loop that generates an epigenetic switch that links inflammation to cancer. xref Thus, miR-21 can both positively and negatively control the NF-κB pathway, depending on the cell type."