IndraLab

Statements


USP18 binds ISG15 and UBL. 3 / 3
| 3

sparser
"The crystal structure of mouse USP18 in complex with mouse ISG15 displayed extensive interaction between the ISG15 C-terminal Ubl domain and the palm and thumb domain of USP18 (Basters et al., 2017)."

sparser
"However, only the C-terminal Ubl domain of ISG15 interacts with USP18 whereas no interaction between the N-terminal Ubl domain and USP18 was detected and the presence of the N-terminal domain of ISG15 is dispensable for the deISGylation activity of USP18."

sparser
"Structural data demonstrated that only the ISG15 C-terminal but not the N-terminal UBL domain binds USP18."