IndraLab

Statements

USP18 binds ISG15 and UBL. 4 / 4
| 4
sparser
"Structural data demonstrated that only the ISG15 C-terminal but not the N-terminal UBL domain binds USP18."
32039148
sparser
"The crystal structure of mouse USP18 in complex with mouse ISG15 displayed extensive interaction between the ISG15 C-terminal Ubl domain and the palm and thumb domain of USP18 (Basters et al., 2017)."
32039148
sparser
"However, only the C-terminal Ubl domain of ISG15 interacts with USP18 whereas no interaction between the N-terminal Ubl domain and USP18 was detected and the presence of the N-terminal domain of ISG15 is dispensable for the deISGylation activity of USP18."
30126853
sparser
"The crystal structure of mouse USP18 in complex with mouse ISG15 displayed extensive interaction between the ISG15 C-terminal Ubl domain and the palm and thumb domain of USP18 (Basters et al., xref )."
32039148