IndraLab

Statements

Phosphorylated TP53 is transcriptionally active. 3 / 3
3 |
bel
"We concluded that H7 inhibits constitutive C-terminal phosphorylation of p53, which regulates its turnover in unstressed cells."
11431470
bel
"In the p53-dependent pathway, p53 accumulates following E2F1 expression [29] through activation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) transcript p14ARF, which in turn interacts with mouse double minutes (MDM2), thereby preventing MDM2 from targeting p53 for ubiquitination and subsequent degradation"
16530485
bel
"Furthermore, evidence is provided that increased Cdk5 activity increases p53 transcriptional activity significantly, suggesting that p53 is modulated in situ by Cdk5. This is the first demonstration that p53 is a substrate of Cdk5, and that Cdk5 can modulate p53 levels and activity."
12064478