IndraLab

Statements

SNAI1 binds PSMD14. 16 / 22
6 | 5 11
reach
"Besides, PSMD14 could associate with snail, which inhibits snail poly-ubiquitination and degradation in esophageal cancer [27]."
38017133
sparser
"The deubiquitinating enzyme PSMD14 directly interacts with Snail and stabilizes it to promote cell migration and tumor metastasis of esophageal squamous cell carcinoma ( xref )."
35445731
reach
"In esophageal carcinoma [9], PSMD14 inhibitors can diminish the association between PSMD14 and Snail, promote Snail ubiquitination and degradation, limit EMT, and inhibit ESCC cell metastasis, stemness, and chemotherapy sensitivity."
38053170
sparser
"To verify the result of the mass spectrometry, we performed a co-immunoprecipitation assay to test the interaction between SNAIL and PSMD14 in HEK293T cells ( Fig. 1 B)."
29331416
sparser
"Collectively, these results indicate that PSMD14 interacts with SNAIL and their interaction is mediated through the serine-proline rich domain of SNAIL."
29331416
sparser
"In conclusion, our findings suggest that the deubiquitinating enzyme PSMD14 could interact with SNAIL and reverse its degradation through removing the poly-ubiquitin chains, thereby inducing EMT proce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29331416
sparser
"Our findings demonstrated that PSMD14 could bind with SNAIL and inhibit its ubiquitination to reverse the degradation process."
29331416
sparser
"Mechanically, THL impaired the interaction between PSMD14 and SNAIL, then promoted the ubiquitination and degradation of SNAIL to inhibit EMT which plays a crucial role in ESCC metastasis, stemness and chemosensitivity."
33897885
sparser
"Besides, PSMD14 could associate with snail, which inhibits snail poly-ubiquitination and degradation in esophageal cancer [ xref ]."
38017133
reach
"Interestingly, thiolutin was recently found in a model of oesophageal carcinoma to suppress motility and stemness and to increase sensitivity to cisplatin both in vitro and in vivo, by impairing the interaction between POH1 and SNAIL, a substrate of the proteasome with a role in EMT [64]."
35501388
sparser
"THL weakens the interaction between PSMD14 and SNAIL to accelerate the degradation of SNAIL."
33897885
sparser
"Furthermore, co-immunoprecipitation assay was conducted to test the impact of THL on the interaction between PSMD14 and SNAIL in ESCC cells."
33897885
sparser
"Meanwhile, the level of SNAIL which interacts with PSMD14 was also reduced when ESCC cells were exposed to THL (Figure xref I and xref J)."
33897885
reach
"To verify the result of the mass spectrometry, we performed a co-immunoprecipitation assay to test the interaction between SNAIL and PSMD14 in HEK293T cells ( Fig. 1 B)."
29331416
sparser
"Interestingly, thiolutin was recently found in a model of oesophageal carcinoma to suppress motility and stemness and to increase sensitivity to cisplatin both in vitro and in vivo, by impairing the interaction between POH1 and SNAIL, a substrate of the proteasome with a role in EMT [ xref ]."
35501388
reach
"Our findings demonstrated that PSMD14 could bind with SNAIL and inhibit its ubiquitination to reverse the degradation process."
29331416