IndraLab

Statements


5 1 | 2 1

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"FLAG-PABPC1 seems to have the same function as that of endogenous PAPBC1, and the indirect binding between PABPC1 and PAN2 or AGO2 is partially RNA dependent."

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"Mangus et al. have shown that Pbp1 negatively regulates Pan2 deadenylase by disturbing the Pab1-Pan2 interaction, and that the cell extract from pbp1Δ single mutant in the stationary phase has stronger deadenylase activity than that in WT in vitro [ xref , xref ]."

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"However, in the RNase A treatment group, the amounts of co-IPed AGO2 and PAN2 were partially reduced, which means that the interactions between PABPC1, AGO2, and PAN2 are partially dependent on RNA molecules."

No evidence text available