IndraLab

Statements

BAP1 activates TNFSF10. 4 / 4
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"rTRAIL sensitivity of the parental BAP1-null H226 MM line was significantly diminished following expression of wild-type BAP1 and each of the mutant constructs except those with an inactive deubiquitinating or ASXL protein binding site (XREF_FIG), implicating the function of these sites in BAP1 induced TRAIL resistance."
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"BAP1 modulates TRAIL sensitivity through PR-DUB activity."
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"While we highlight the extrinsic apoptotic pathway and proteins as being significantly altered by BAP1 status, identifying a single factor to explain BAP1 induced TRAIL resistance is extremely challenging."
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"To elucidate the mechanism by which BAP1 modulates sensitivity to TRAIL we generated expression vectors containing wild-type or mutant forms of BAP1, each with an inactive functional site or protein binding domain."
29345617