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IKK_family phosphorylates CYLD. 5 / 5
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"Based on these prior reports and the data obtained thus far with the MT4 cells, we hypothesized that TAX activation of IKK family of kinases induces the phosphorylation of CYLD to suppress its deubiquitinating activity."
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"IKK family kinases phosphorylate CYLD in the ATLL MT4 cell line."
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"It is likely that the IKK family phosphorylates multiple targets including RIPK1 and CYLD, all with the goal of inhibiting RIPK1-mediated cell death.To understand further the role that CYLD phosphorylation may be playing in ATLL pathogenesis, we analyzed this modification in HTLV-1 transformed T-cell lines, representative of ATLL, as well as in primary human ATLL samples."
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"We now report that phosphorylation of CYLD by IKK family kinases in HTLV-1 transformed T cells inhibits RIPK1 from activating the cell death pathway and inhibiting these kinases reactivates CYLD and RIPK1-dependent tumor cell death."
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"TNFα stimulation has also been shown to lead to phosphorylation of A20 and CYLD by IKK complex as well as activation of p38 xref – xref ."
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