IndraLab

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NGF bound to its activates NTRK1. 2 / 2
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"Specifically, the binding of NGF to its receptors promotes the formation of trkA homodimers and trkA-p75 NTR heterodimers and the autophosphorylation of the receptors, which then activate downstream signalling cascades such as mitogen activated protein kinases (MAPK), also known as extracellular signal regulated kinases (ERKs), and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (PKB, also known as AKT), resulting in enhanced neuronal survival and growth."
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"The NGF binding to its receptor potentiates an unprecedented GPCR signaling via membrane Galphai subunit proteins and MMP-9 activation to induce the activation of Neu1 sialidase in live primary neurons and TrkA- and TrkB expressing cell lines, as depicted in XREF_FIG."
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