IndraLab

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Protease deubiquitinates ZUP1. 6 / 6
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"Analysis of enzymatic activity and structural studies revealed that SARS-CoV PLpro and HCoV-NL63 PLP2 function as both proteases and deubiquitinating (DUB) enzymes [14], [32]–[35]."
22312431
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"One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN)."
20181693
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"Coronavirus papain-like proteases (PLPs) can act as proteases that process virus-encoded large replicase polyproteins and also as deubiquitinating (DUB) enzymes."
28316013
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"The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity.Coronavirus papain-like proteases (PLPs) can act as proteases that process virus-encoded large replicase polyproteins and also as deubiquitinating (DUB) enzymes."
28316013
reach
"Analysis of enzymatic activity and structural studies revealed that SARS-CoV PLpro and HCoV-NL63 PLP2 function as both proteases and deubiquitinating (DUB) enzymes [14, [32] [33] [34] [35] ."
22312431
reach
"Abstract Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection."
24503068