IndraLab

Statements

TP53 binds USP10. 51 / 53
7 | 17 27
sparser
"In unstressed cells, it was shown that USP10 binds, deubiquitinates and stabilizes p53 in the cytoplasm, antagonizing Mdm2-mediated p53 nuclear export and degradation."
32201366
biogrid
No evidence text available
24998844
sparser
"USP10 is also associated with regulation of p53 localization and stability, however, unlike USP2 and USP7, it does not interact with MDM2 [ xref ]."
25972356
biogrid
No evidence text available
24998844
reach
"The inhibition of the proline hydroxylase PHD3 could significantly reduce the binding of USP10 to p53 [35]."
35627217
sparser
"G3BP1 disrupts the interaction of USP10 with p53."
24998844
reach
"IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) inhibits p53 expression through disrupting the interaction between USP10 and p53 and promotes lung cancer progression [37]."
35627217
sparser
"These results suggest that G3BP1 interrupts the interaction of USP10 with p53 by its own interaction with USP10."
24998844
sparser
"Similar to what we observed with USP7, inhibition of hydroxylase activity diminished the interaction between p53 and endogenous USP10."
30067985
reach
"In other words, in the presence of p53, USP10 largely binds p53 and stabilizes p53 under the stress conditions."
32382008
biogrid
No evidence text available
20096447
biogrid
No evidence text available
20096447
sparser
"As a mechanism of resveratrol-induced p53 expression, we revealed that resveratrol directly binds to G3BP1 and disrupts the G3BP1/USP10 interaction, releasing USP10 which in turn results in enhanced USP10-mediated deubiquitination of p53."
24998844
reach
"These results suggest a specific interaction between USP10 and p53 in vivo."
20096447
reach
"Interestingly, the USP10 and p53 interaction was increased by treatment with resveratrol."
24998844
sparser
"It is also revealed that TRAF4 interacts with the deubiquitinating enzymes USP10, blocks the binding of p53 to USP10 and induce p53 instability [ xref , xref ]."
35054492
sparser
"Purified His-USP10 was able to interact with GST-p53 under cell-free conditions, suggesting a direct interaction between USP10 and p53 ( xref )."
20096447
reach
"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation ."
31745110
sparser
"In line with this, some studies found that the disruption of the interaction between USP10 and p53 inhibited cancer cells' viability or tumor growth."
35627217
sparser
"USP10 (ubiquitin-specific protease 10) is another de-ubiquitinase enzyme that regulates the levels of p53 by controlling p53 ubiquitination and stability. xref , xref Unlike HAUSP, USP10 can interact only with p53, and not with MDM2."
32532965
sparser
"In this study, we found that G3BP1 enhances the p53 ubiquitination by disrupting the interaction of USP10 with p53, leading to destabilization of p53."
24998844
sparser
"Unlike HAUSP, a previously identified deubiquitinase for p53 and Mdm2, USP10 only interacts with p53, but not Mdm2."
20096447
sparser
"Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1-100) binds to p53 and inhibits its ubiquitination [27] ."
35627217
reach
"USP10 interacts with p53 and stabilizes p53."
20096447
biogrid
No evidence text available
20096447
sparser
"G3BP1 binds to USP10 and therefore disrupts the interaction of USP10 with p53, leading to suppression of p53 deubiquitination."
24998844
sparser
"Mapping the region of USP10 required for p53 binding revealed that the N-terminal region (AA1–AA100) is critical for the interaction between USP10 and p53 ( xref )."
20096447
reach
"As shown in XREF_SUPPLEMENTARY, nuclear USP10 is still able to bind and deubiquitinate p53."
20096447
biogrid
No evidence text available
24998844
sparser
"To confirm the hydroxylation-dependent regulation of the p53-USP10 interaction, we performed an analogous experiment."
30067985
sparser
"We conjectured that G3BP1 disrupts the interaction of USP10 with p53 by binding to USP10, and consequently suppresses USP10-mediated deubiquitination of p53."
24998844
reach
"Unlike HAUSP, a previously identified deubiquitinase for p53 and Mdm2, USP10 only interacts with p53, but not Mdm2."
20096447
sparser
"To determine whether the USP10-p53 interaction is direct, we generated and purified recombinant USP10 and p53."
20096447
biogrid
No evidence text available
20096447
sparser
"In addition, an in vitro competition assay showed that the in vitro interaction between USP10 and p53 was clearly decreased in the presence of G3BP1 ( xref )."
24998844
sparser
"As shown in xref , nuclear USP10 is still able to bind and deubiquitinate p53."
20096447
reach
"Mapping the region of USP10 required for p53 binding revealed that the N-terminal region (AA1-AA100) is critical for the interaction between USP10 and p53 (XREF_FIG)."
20096447
reach
"The results indicated that overexpression of G3BP1 decreased the USP10 and p53 interaction as shown by co-IP assays using USP10 antibodies in HCT116 cells (XREF_FIG)."
24998844
sparser
"USP10 interacts with p53 and stabilizes p53."
20096447
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
sparser
"Furthermore, P359A mutation reduced the interaction with USP10 in comparison to p53 wt and the interaction between the p53-P359A and USP10 was not regulated by DMOG ( Figure 5 D)."
30067985
reach
"USP10 directly interacts with p53 to remove Ub, while USP7 seems to preferentially target MDM2 [2,7,8]."
28284458
sparser
"By serendipity, we found that the ubiquitin specific protease USP10 interacts with p53."
20096447
sparser
"In other words, in the presence of p53, USP10 largely binds p53 and stabilizes p53 under the stress conditions."
32382008
reach
"Consistently, down-regulation of G3BP1 increased the USP10 and p53 interaction in SK-MEL-5 cells (XREF_FIG)."
24998844
reach
"In line with this, some studies found that the disruption of the interaction between USP10 and p53 inhibited cancer cells’ viability or tumor growth."
35627217
sparser
"According to a previous report ( xref ), the N-terminal region of USP10 (residues 1–100) interacts with p53 to deubiquitinate p53."
24998844
sparser
"IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) inhibits p53 expression through disrupting the interaction between USP10 and p53 and promotes lung cancer progression [37] ."
35627217
sparser
"These results suggest a specific interaction between USP10 and p53 in vivo ."
20096447
reach
"Without the disruption of the p53/USP10 complex by G3BP1, p53-deubiquitination results were affected, leading to its proteasomal degradation.SET7/9 methyltransferases regulate p53 through monomethylation in Lys372, resulting in protein stabilization and activation."
34744708
reach
"Purified His USP10 was able to interact with GST-p53 under cell-free conditions, suggesting a direct interaction between USP10 and p53 (XREF_FIG)."
20096447