IndraLab

Statements

USP15 deubiquitinates TGFBR1. 8 / 9
1 | 8
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"For example, the closely related DUBs USP4, USP11 and USP15 have been reported to modulate TGFbeta signalling by deubiquitylating the type I TGFbeta receptor ALK5 [XREF_BIBR - XREF_BIBR]."
24850914
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"USP15 binds to the Smad7 and Smurf2 complex and, like USP4 and USP11, deubiquitinates the TGF-beta type I receptor, thereby maintaining the stability of this receptor and enhancing TGF-beta signalling[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27155333
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"The authors hypothesized that USP15 was up-regulated and enhanced the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TGF-beta receptor I (TbetaRI) in vitro."
34546211
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"It has been revealed that the DUBs, UCH37, USP11, and USP15, de-ubiquitinate and stabilize TbetaRI."
27853171
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"Preliminary results by Ten Dijke and colleagues add weight to this theory whereby they identified that the ability of USP15 to deubiquitinate TbetaRI requires USP4, as USP15 was unable to perform this[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
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"Co-immunoprecipitation and ubiquitination assays revealed that USP15 interacted with TbetaRI and deubiquitinated TbetaRI."
34546211
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"Ubiquitin-specific peptidase 15 (USP15), a deubiquitinating enzyme, binds to the SMAD7-SMURF2 complex and deubiquitinates and stabilizes TGFBR1, resulting in enhanced TGF-β signaling ."
35017630
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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
27853171