IndraLab
Statements
reach
"Importantly, TBKBP1 knockdown severely impaired EGF stimulated phosphorylation of mTORC1 target proteins, S6K and S6, without affecting the phosphorylation of AKT, and the mTORC1 signaling defect could be rescued by reconstituting the Tbkbp1-knockdown cells with TBKBP1 (XREF_FIG)."
reach
"We determined that EGF activates phosphorylation of Akt, mTOR, p70S6 kinase, ribosomal protein S6, eIF4E and 4E-BP1 in a PI-3-kinase dependent manner, and PI-3-kinase activation may prevent lactogenic differentiation in HC11 mammary epithelial cells by regulating the synthesis of proteins."
sparser
"Biochemical analyses confirmed that CC214-1 successfully inhibited mTORC1 dependent 4E-BP1 and S6 phosphorylation in EGFRvIII-expressing GBM cells ( xref and xref , xref ), as well as blocked EGF-induced 4E-BP1 and S6 phosphorylation in GBM cells overexpressing wild type EGFR ( xref )."