IndraLab
Statements
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"Surprisingly, USP4 knockdown also reduces the levels of SKP2 and CDH1 pointing to distortions in the dynamic equilibrium between APC/C and SCF ."
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"In line with previous studies, we also showed that USP4 promoted melanoma metastasis by suppressing E-cadherin expression and increasing N-cadherin expression, indicating the ubiquitous existence of the crosstalk between USP4 and EMT in different kinds of cancer."
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"We found that knockdown of both USP4 and beta-catenin downregulated the expression of ZEB1 and thereby increased the level of E-cadherin, indicating that the USP4 and beta-catenin axis is required for the EMT process and involves the regulation of ZEB1."
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"Importantly, depressed expression of USP4 inhibited TβRI expression and partially reversed EMT stimulated by TGF-β1.In the meantime, blunted phosphorylation of Akt promoted the E-cadherin expression, and inhibited α-SMA and Vimentin expression in response to TGF-β1."