IndraLab

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Modified UCHL1 increases the amount of NADPH. 4 / 4
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"Quantitative analyses of the ratio of NADPH to NADP + (NADPH and NADP +) and that of GSH to GSSG (GSH and GSSG) revealed that the aberrant overexpression of UCHL1 increased intracellular levels of both NADPH and GSH."
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"In agreement with these results, luciferase assay based quantification experiments also confirmed that overexpression of UCHL1 significantly increased the intracellular levels of both NADPH and GSH in a pentose phosphate pathway dependent manner."
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"UCHL1 overexpression induced the reprogramming of carbohydrate metabolism and increased NADPH levels in a pentose phosphate pathway (PPP)-dependent manner."
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"In detail, we found that UCHL1 overexpression induced the reprogramming of carbohydrate metabolism from oxidative phosphorylation to glycolysis in a HIF-1-dependent manner, and consequently increased [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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