IndraLab

"We have recently reported that the hypertension in response to placental ischemia is associated with increases in plasma levels of sFlt-1, sEng, TNF-α, and AT1-AA. xref , xref We also demonstrated that chronic infusion of TNF-α or AT1-AA, at rates to mimic the increase of these factors observed in placental ischemic pregnant rats, significantly contributes to elevated blood pressures. xref – xref Moreover, we found that chronic infusion of TNF-α in pregnant rats stimulated the production of AT1-AA and the blood pressure response to TNF-α or AT1-AA were attenuated by treatment with an angiotensin type 1 receptor antagonist. xref , xref Although these findings suggest an important interaction between TNF-α and AT1-AA in the blood pressure response to placental ischemia, it is unknown whether these factors interact in regulating sFlt-1 and sEng production."

"Moreover, TNF-alpha-induced hypertension (97+/-2 to 112+/-2 mm Hg; P<0.05) in pregnant rats was associated with AT1-AA production (TNF-alpha rats 9.2+/-2.3 U versus NP rats 1.0+/-0.8 U; P<0.05)."

"Moreover, TNF- α –induced hypertension (97±2 to 112±2 mm Hg; P <0.05) in pregnant rats was associated with AT1-AA production (TNF- α rats 9.2±2.3 U versus NP rats 1.0±0.8 U; P <0.05)."