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"SAP97 and Kv1.5 subunits can interact, directly or indirectly, both in the heart and in heterologous systems. xref , xref Adenoviral overexpression of SAP97 in neonatal rat atrial myocytes leads to clustering of endogenous Kv1.5 subunits at myocyte-myocyte contacts and an increase in both I Kur and the number of 4-aminopyridine-sensitive potassium channels in cell-attached membrane patches. xref On the other hand, pull-down and coimmunoprecipitation assays in cardiac myocytes showed that the Kv4 channel C terminus, SAP97, and CaMKII interact together, and that the interaction is suppressed by SAP97 silencing and enhanced by SAP97 overexpression. xref In HEK293 cells, SAP97 silencing reproduced the effects of CaMKII inhibition on current kinetics and suppressed Kv4/CaMKII interactions."