IndraLab

Statements

KCNMA1 activates cell death. 12 / 12
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"Examples include the PFT from Bacillus anthracis that causes pyroptosis of macrophages, and SLO that induces cell death by pyroptosis in mouse bone marrow derived macrophages [XREF_BIBR, XREF_BIBR]."
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"However, a combination of SLO with recombinant granzyme B indeed caused substantial cell death as indicated by ATP reduction, AST elevation, and CK-18 cleavage."
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"Excitingly, addition of the specific BK channel activator, NS11021, to the CS solution partially protects transplanted rat kidneys against CS+Tx-induced mitochondrial respiratory dysfunction, oxidative protein nitration, and cell death."
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"Using an in vitro model of renal CS, we recently reported that pharmacological activation of the mitochondrial BK channel (mitoBK) during CS protected against CS-induced mitochondrial injury and cell death."
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"SLO can trigger macrophage and neutrophil cell death and/or the inactivation of immune cell functions, and promotes tissue injury and bacterial survival in animal models of infection."
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"In contrast to the observations with alpha-toxin, recovery of ATP after attack by SLO proved not to be impaired by SB203580, and SLO mediated cell death as assessed by Trypan-blue staining 48 h after [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, concentrations of SLO that induced < 20% cell death at 5 min led to> 60% death by 30 min (XREF_FIG A, C)."
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"SLO also silences neutrophil function by damaging phagolysosomal membranes and inducing cell death (Sierig et al., 2003)."
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"SLO can also trigger membrane damage and cytolytic cell death in keratinocytes, which may play a role in the severe tissue injury of invasive GAS necrotizing skin infection."
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"Upon macrophage phagocytosis, SLO activity causes a dose dependent form of apoptotic cell death among a population of infected cells."
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"In accordance with previous studies XREF_BIBR, destabilization of the actin cortex protected HEK 293 cells from SLO induced cell death (XREF_FIG)."
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"Previously, we showed that SLO acts combinatorially with either of the two enzymatic haplotypes of SPN to cause accelerated cell death in HeLa cells, A549 epithelial cells, and HaCaT keratinocytes and that NADase + SPN causes necrosis via the process of metabolic catastrophe."
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